Introduction to Mechanisms in Pharmacology and Therapeutics (eBook)

Howard Rogers, Roy G. Spector (Autoren)

eBook Download: PDF

2013 | 1. Auflage
420 Seiten
Elsevier Science (Verlag)
978-1-4831-9551-3 (ISBN)

Infos

An Introduction to Mechanisms in Pharmacology and Therapeutics aims to provide some extra information and background reading on modes of action of drugs, but it is not meant to replace existing pharmacology textbooks. It also attempts to show the connection between cell biology and the practice of clinical medicine. This book is organized into 13 chapters that discuss drug-receptor interactions and the influence of drugs on the nervous, respiratory, circulatory, and alimentary systems. They also explain the concepts of pharmacogenetics, intracellular control mechanisms, chemotherapy, and the different types of drugs. This book will be of interest to preclinical and clinical medical students and those preparing for Bachelor of Science degree in Pharmacology and others interested in understanding how drugs work.

Inhalt

Front Cover 1
An Introduction to Mechanisms in Pharmacology and Therapeutics 4
Copyright Page 
5 
Table of Contents 6
Preface 8
Chapter 1. The Cell and Drugs 10
SUMMARY 13
REFERENCES 14
Chapter 2. Drug-Receptor Interactions 15
FORCES BINDING THE DRUG TO THE RECEPTOR 17
THE MATHEMATICAL ANALYSIS OF DRUG-RECEPTOR COMBINATION 26
THE EFFECT OF DRUG BINDING ON THE RECEPTOR 39
REFERENCES 47
Chapter 3. Cell Membranes 49
PHYSICAL EFFECTS OF DRUGS ON MEMBRANES 57
REFERENCES 59
Chapter 4. Drugs and Intracellular Control Mechanisms 60
(a) CALCIUM AND EXCITATION-RESPONSE COUPLING 60
(b) CHEMICAL CONTROL OF TRANSMITTER RELEASE AND ACTIVITY 68
(c) DRUGS WHICH AFFECT THE CONTROL OF BLOOD GLUCOSE 77
(d) BLOOD LIPID LOWERING AGENTS 89
(e) THE INFLUENCE OF DRUGS ON FOLATE METABOLISM 94
REFERENCES 99
Chapter 5. The Fate of Drugs in the Body 101
PROTEIN BINDING 103
"METABOLIC HALF-LIFE" 104
METABOLIC CONVERSIONS 105
CONJUGATION REACTIONS 111
FACTORS WHICH MODIFY DRUG METABOLISM 115
DRUG EXCRETION 117
REFERENCES 118
Chapter 6. Pharmacogenetics 119
FREQUENTLY OCCURRING CONDITIONS 119
RARE CONDITIONS 124
OTHER FACTORS PRODUCING VARIABILITY IN DRUG RESPONSE 126
REFERENCES 126
Chapter 7. The Nervous System 127
ACETYLCHOLINE 130
THE ADRENERGIC NERVOUS SYSTEM 137
THE NEUROMUSCULAR JUNCTION 153
ANAESTHETICS 155
LOCAL ANAESTHETICS 162
HYPNOTICS 164
ANXIOLYTIC DRUGS 172
ANTIDEPRESSANT DRUGS 174
THE MAJOR TRANQUILLISERS 180
ANTICONVULSANTS 186
ANTI-PARKINSONIAN DRUGS 190
DRUG-INDUCED PARKINSONISM 192
THE NARCOTIC ANALGESICS 192
ALCOHOL 199
MIGRAINE 203
REFERENCES 207
Chapter 8. Anti-inflammatory Analgesics Gout Antihistamines
ANTI-INFLAMMATORY ANALGESICS (MINOR ANALGESICS) 209
GOUT 213
HISTAMINE 214
SOME MECHANISMS OF ACTION OF IMMUNOSUPPRESSIVE DRUGS 217
IMMUNOSUPPRESSIVE DRUGS 219
REFERENCES 223
Chapter 9. Circulatory System 224
ANTIARRHYTHMIC DRUGS 224
AUTONOMIC CONTROL OF THE HEART 
241 
VASOACTIVE DRUGS 245
VASODILATOR DRUGS 249
THE CONTROL OF BLOOD PRESSURE 251
ANTI-ANGINAL DRUGS 266
CARDIAC GLYCOSIDES 272
REFERENCES 282
Chapter 10. Drugs acting on the Respiratory System 284
CHEMICAL CONTROL OF RESPIRATION 284
AIRWAYS OBSTRUCTION 291
COUGH 309
REFERENCES 314
Chapter 11. The Diuretic Drugs 315
THE NORMAL NEPHRON 315
METHODS OF DETERMINING SITES OF ACTION OF DIURETICS 316
GROUPS OF DIURETICS 318
POTASSIUM DEPLETION 325
THE USE OF DIURETICS 326
REFERENCES 327
Chapter 12. The Alimentary System 328
APPETITE DEPRESSANT DRUGS 328
DRUGS USED IN THE TREATMENT OF OESOPHAGEAL DISORDERS 330
ANTIEMETICS 331
5-HYDROXYTRYPTAMINE (5-HT) 334
THE CONTROL OF GASTRIC SECRETION AND PEPTIC ULCERATION 337
DRUGS USED TO CONTROL DIARRHOEA 351
LAXATIVES AND PURGATIVES 353
THE LIVER AND BILIARY APPARATUS 355
GALLSTONES 359
REFERENCES 361
Chapter 13. Chemotherapy 362
ANTIBACTERIAL DRUGS 362
ANTIVIRAL CHEMOTHERAPY 382
ANTIMALARIALS 384
LEISHMANIASIS AND SCHISTOSOMIASIS 387
TRYPANOSOMIASIS 389
FILARIASIS 389
AMOEBIASIS 390
ANTHELMINTICS 390
ANTITUMOUR DRUGS 391
STRATEGY OF THE USE OF ANTICANCER DRUGS 400
REFERENCES 404
Index 405

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• ISBN-10: 1-4831-9551-1 / 1483195511
• ISBN-13: 978-1-4831-9551-3 / 9781483195513