The Population Biology of Tuberculosis

Christopher Dye (Autor)

Buch | Hardcover

296 Seiten

2015
Princeton University Press (Verlag)
978-0-691-15462-6 (ISBN)

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Despite decades of developments in immunization and drug therapy, tuberculosis remains among the leading causes of human mortality, and no country has successfully eradicated the disease. Reenvisioning tuberculosis from the perspective of population biology, this book examines why the disease is so persistent and what must be done to fight it. Treating tuberculosis and its human hosts as dynamic, interacting populations, Christopher Dye seeks new answers to key questions by drawing on demography, ecology, epidemiology, evolution, and population genetics. Dye uses simple mathematical models to investigate how cases and deaths could be reduced, and how interventions could lead to TB elimination. Dye's analysis reveals a striking gap between the actual and potential impact of current interventions, especially drug treatment, and he suggests placing more emphasis on early case detection and the treatment of active or incipient tuberculosis. He argues that the response to disappointingly slow rates of disease decline is not to abandon long-established principles of chemotherapy, but to implement them with greater vigor.
Summarizing epidemiological insights from population biology, Dye stresses the need to take a more inclusive view of the factors that affect disease, including characteristics of the pathogen, individuals and populations, health care systems, and physical and social environments. In broadening the horizons of TB research, The Population Biology of Tuberculosis demonstrates what must be done to prevent, control, and defeat this global threat in the twenty-first century.

Christopher Dye is the Director of Strategy in the Office of the Director General at the World Health Organization, Geneva. He has been the Gresham Professor of Physic in London and a visiting professor of zoology at the University of Oxford. His work has appeared in many publications including Science, Nature and The Lancet.

Preface vii Chapter 1 Tuberculosis Undefeated 1 Chapter 2 Concepts and Models 26 Chapter 3 Risk and Variation 64 Chapter 4 Interventions and Control 100 Chapter 5 Strains and Drug Resistance 138 Chapter 6 TB and HIV/AIDS 162 Chapter 7 Elimination and Eradication 190 Chapter 8 Populations and Social Diseases 207 Appendix 1 Derivation of the Basic Case Reproduction Number and Epidemic Doubling Time 219 Appendix 2 Formal Description of the Standard Model 222 References 227 Index 271

Reihe/Serie	Monographs in Population Biology
Zusatzinfo	85 halftones. 7 tables.
Verlagsort	New Jersey
Sprache	englisch
Maße	152 x 235 mm
Gewicht	624 g
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Studium ► Querschnittsbereiche ► Prävention / Gesundheitsförderung
	Naturwissenschaften ► Biologie
ISBN-10	0-691-15462-7 / 0691154627
ISBN-13	978-0-691-15462-6 / 9780691154626
Zustand	Neuware