Teratogens (eBook)

Chemicals Which Cause Birth Defects

Vera M. Kolb (Herausgeber)

eBook Download: PDF

2013 | 2. Auflage
594 Seiten
Elsevier Science (Verlag)
978-1-4831-9322-9 (ISBN)

Infos

Teratogens Chemicals Which Cause Birth Defects, 2nd Revised Edition is a collection of papers that discusses the practical aspect of teratogens, particularly regarding information on the teratogenic potential of chemicals. This book describes the principles and mechanism of teratogenesis, including the initiating mechanisms during the subcellular or molecular level and the role of bio-activation in teratogenesis. Investigations have been done on the relationship between spontaneous abortion in women exposed to organic solvents, antineoplastic agents, and chemicals in plastics. Other studies also show that teratogenicity depends in part on enzymatic bio-activation to an embryotoxic reactive intermediate. This text also explains the legal and ethical aspects of fetal protection policies with emphasis on fetal protection. Protection to expecting women extends to pregnant students exposed to teratogenic chemicals in chemistry laboratories. The book explains how and where to get information about the teratogenic potential of chemicals and how to properly handle these chemicals in the laboratory. The book also provides a list from RTECs of toxic chemicals which can cause reproductive effects. This book can prove useful for chemists, pharmacologists, obstetricians, gynecologists, and practitioners of general medicine.

Inhalt

Front Cover 1
Teratogens Chemicals which Cause Birth Defects 4
Copyright Page 5
Table of Contents 8
PREFACE 6
Chapter 1. PRINCIPLES AND MECHANISMS OF TERATOGENESIS 10
1. HISTORICAL ASPECTS 10
2. DEFINITIONS 11
3. GENERAL PRINCIPLES OF TERATOLOGY 11
4. INITIATING MECHANISMS OF TERATOGENESIS 15
5. HUMAN TERATOGENS: EXAMPLES AND TYPES OF EFFECTS 17
6. ROLE OF BIOACTIVATION IN TERATOGENESIS 21
7. CONCLUSIONS 27
REFERENCES 27
Chapter 2. Maternal occupational exposure and spontaneous abortion 29
INTRODUCTION 29
EPIDEMIOLOGY OF SPONTANEOUS ABORTION 29
SOME MECHANISMS FOR THE EFFECTS OF ENVIRONMENTAL 
31 
OCCUPATIONAL EXPOSURE AND SPONTANEOUS ABORTION 32
CONCLUSIONS 45
ACKNOWLEDGMENTS 45
REFERENCES 46
Chapter 3. BIOCHEMICAL DETERMINANTS OF CHEMICAL TERATOGENESIS: STUDIES WITH PHENYTOIN, BENZO(A)PYRENE AND RELATED XENOBIOTICS 49
REACTIVE INTERMEDIATES 49
TERATOGENICITY OF PHENYTOIN AND STRUCTURALLY RELATED 
49 
UDP-GLUCURONOSYLTRANSFERASES (UGTs) AND BENZO(A)PYRENE TERATOGENESIS 55
SUMMARY 58
ACKNOWLEDGEMENTS 59
REFERENCES 59
Chapter 4. LEGAL AND ETHICAL ASPECTS OF FETAL PROTECTION POLICIES 63
EQUAL EMPLOYMENT OPPORTUNITY 65
EEO AND FETAL PROTECTION POLICIES 70
IMPLICATIONS FOR EMPLOYERS 76
REFERENCES 80
Chapter 5. TERATOGENIC CHEMICALS IN UNDERGRADUATE CHEMISTRY LABORATORIES 84
1. WHAT SUBSTANCES ARE PRESENT IN UNDERGRADUATE LABORATORIES? 85
2. WHICH COMPOUNDS ARE TERATOGENIC? 86
3. POTENTIAL TERATOGENS IN CHEMISTRY LABORATORY MANUALS 88
4. TYPES OF TERATOGENS 93
5. THE UNIQUE HAZARDS OF TERATOGENS 97
6. THE MICROSCALE LABORATORY 98
7. CONCLUSION 99
REFERENCES 100
Chapter 6. HOW TO OBTAIN INFORMATION ABOUT THE TERATOGENIC POTENTIAL OF 
102 
INTRODUCTION 102
THE LITERATURE OF TERATOLOGY 104
DATABASES SPECIALIZING IN TERATOLOGY AND DEVELOPMENTAL/REPRODUCTIVE TOXICITY INFORMATION 105
CONCLUSION 123
ACKNOWLEDGEMENTS 123
REFERENCES 124
Chapter 7. REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES AS A SOURCE FOR COMPILING A LIST OF TERATOGENS 125
REFERENCES 127
LIST OF CHEMICALS FROM RTECs WHICH CAUSE REPRODUCTIVE EFFECTS 128
Chapter 8. SAFE HANDLING OF TERATOGENIC CHEMICALS IN THE LABORATORY 591
NEW DEVELOPMENTS 591
LITERATURE 592
CONCLUSION 592
REFERENCES 592
SUBJECT INDEX 593

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber ► Gesundheit / Leben / Psychologie ► Krankheiten / Heilverfahren
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik
• ISBN-10: 1-4831-9322-5 / 1483193225
• ISBN-13: 978-1-4831-9322-9 / 9781483193229