Developmental and Cellular Skeletal Biology (eBook)

Brian K. Hall (Autor)

eBook Download: PDF

2013 | 1. Auflage
314 Seiten
Elsevier Science (Verlag)
978-1-4832-6721-0 (ISBN)

Infos

Developmental and Cellular Skeletal Biology reviews the development, growth, and cell biology of the skeleton. The monograph provides a comprehensive overview of the aspects of skeletal biology, focusing mainly on the cellular level. It covers topics on the types of skeletal tissues, its evolution, and origin; location of the skeleton within the embryo; initiation of centers of skeletogenesis; and the initiation of skeletal growth. The book will be of great use to physiologists, cell biologists, hematologists, pathologists, orthopedic surgeons, and others whose professions are concerned with the study of the skeletal system.

I have been interested in and studying skeletal tissues since my undergraduate days in Australia in the 1960s. Those early studies on the development of secondary cartilage in embryonic birds, first published in 1967, have come full circle with the discovery of secondary cartilage in dinosaurs12. Bird watching really is flying reptile watching. Skeletal tissue development and evolution, the embryonic origins of skeletal tissues (especially those that arise from neural crest cells), and integrating development and evolution in what is now known as evo-devo have been my primary preoccupations over the past 50+ years.

Inhalt

Front Cover 1
Developmental and Cellular Skeletal Biology 4
Copyright Page 5
Table of Contents 6
Preface 10
CHAPTER 1. TYPES OF SKELETAL TISSUES 12
I. Introduction 12
II. Bone 12
III. Cartilage 18
IV. Enamel 23
V. Dentine 23
VI. Intermediate Tissues 24
CHAPTER 2. THE EVOLUTION OF SKELETAL TISSUES 32
Text 32
CHAPTER 3. THE ORIGIN OF SKELETAL CELL TYPES 37
I. Stem Cells 37
II. Modulation of Synthetic Activity 40
III. Precursor Cells 43
IV. Specificity of Embryonic Induction 46
CHAPTER 4. LOCATION OF THE SKELETON WITHIN THE EMBRYO 48
I. Introduction 48
II. The Skeleton of the Neural Crest 48
III. The Limb Skeleton 69
IV. The Vertebral Skeleton 89
V. The Auditory Cartilage 93
VI. Ectopic Skeletogenesis 93
CHAPTER 5. INITIATION OF CENTERS OF SKELETOGENESIS 97
I. Introduction 97
II. Mesenchymal Condensations in the Developing Limb Bud 99
III. Mechanisms Invoked for Initiation of Condensations 107
IV. Hyaluronic Acid and the Initiation of Condensations 110
CHAPTER 6. PROGENITOR CELLS AND THEIR DIFFERENTIATION 118
I. Introduction 118
II. Osteo- and Chondroprogenitor Cells 119
III. Progenitor Cells for Osteoblasts and Osteoclasts 120
IV. Progenitor Cells for Osteoblasts and Chondroblasts 123
V. Dedifferentiation as a Source of Progenitor Cells 126
VI. The Differentiation of Progenitor Cells 135
CHAPTER 7. MAINTENANCE OF THE DIFFERENTIATED STATE 159
I. Introduction 159
II. Maintenance of the Differentiated Chondrocyte 160
III. Maintenance of the Differentiated Osteocyte 197
CHAPTER 8. POLARITY AND MORPHOGENESIS 203
I. Introduction 203
II. Establishment of Axes and Polarity during Limb Development 206
III. Mechanisms of Morphogenesis 210
CHAPTER 9. INITIATION OF SKELETAL GROWTH 217
I. Introduction 217
II. Components of Skeletal Growth 218
Appendix 238
Bibliography 240
Author Index 278
Subject Index 296

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Chirurgie ► Unfallchirurgie / Orthopädie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Orthopädie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• Themenwelt: Technik
• ISBN-10: 1-4832-6721-0 / 1483267210
• ISBN-13: 978-1-4832-6721-0 / 9781483267210