Metabolic Bone Disease (eBook)

Volume II

Louis V. Avioli, Stephen M. Krane (Herausgeber)

eBook Download: PDF

2013 | 1. Auflage
734 Seiten
Elsevier Science (Verlag)
978-1-4832-6792-0 (ISBN)

Infos

Metabolic Bone Disease, Volume II describes the clinical disorders of bone and mineral metabolism characterized by elevated levels of circulating parathyroid hormone. This book emphasizes the relationship between hormonal synthesis, biological activity, and abnormalities in specific clinical syndromes. The metabolism and structure-function relationships of parathyroid hormone and other revealing interactions with specific receptors in target organs are also elaborated in this publication, including a basis for some understanding of the parathyroid hormone and vitamin D-'resistant states. Other topics discussed include the fundamental considerations of the physiology and biochemistry of parathyroid hormone; pathogenesis of renal osteodystrophy; and metabolic aspects of Paget's disease. This publication also covers the effects of hypercalcemia and normocalcemic disorders of mineral metabolism. This volume is beneficial to clinicians and students concerned with metabolic bone diseases.

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Metabolic Bone Disease, Volume II describes the clinical disorders of bone and mineral metabolism characterized by elevated levels of circulating parathyroid hormone. This book emphasizes the relationship between hormonal synthesis, biological activity, and abnormalities in specific clinical syndromes. The metabolism and structure-function relationships of parathyroid hormone and other revealing interactions with specific receptors in target organs are also elaborated in this publication, including a basis for some understanding of the parathyroid hormone and vitamin D-"e;resistant states. Other topics discussed include the fundamental considerations of the physiology and biochemistry of parathyroid hormone; pathogenesis of renal osteodystrophy; and metabolic aspects of Paget's disease. This publication also covers the effects of hypercalcemia and normocalcemic disorders of mineral metabolism. This volume is beneficial to clinicians and students concerned with metabolic bone diseases.

Inhalt

Front Cover 1
Metabolic Bone Disease 4
Copyright Page 5
Table of Contents 6
List of Contributors 10
Preface 12
Contents of Other Volumes 14
Chapter 1. Parathyroid Physiology and Primary Hyperparathyroidism 16
I. Introduction 16
II. Fundamental Considerations of the Physiology and Biochemistry of Parathyroid Hormone 19
III. Primary Hyperparathyroidism 63
References 147
Chapter 2. Renal Osteodystrophy 164
I. Introduction 164
II. Pathogenesis of Renal Osteodystrophy 166
III. Clinical and Radiological Correlates 181
IV. Soft Tissue Calcification 192
V. Dialysis Bone Disease 198
VI. The Nature of the Bone Lesions 202
VII. Therapeutic Management 210
References 220
Chapter 3. Hypoparathyroidism 232
I. Postoperative Hypoparathyroidism 233
II. Nonsurgical Damage to the Parathyroid Glands 260
III. Functional Hypoparathyroidism of Diverse Etiology in the Newborn 266
IV. Secondary Hypoparathyroidism Due to Hypercalcemia, with Special Reference to the Newborn Infant of a Hyperparathyroid Mother 272
V. Secondary Hypoparathyroidism Due to Hypermagnesemia 273
VI. Acquired Metabolic Resistance to Parathyroid Hormone 274
VII. Hypoparathyroidism Due to the Secretion of Ineffective Parathyroid Hormone 283
VIII. Idiopathic Hypoparathyroidism 284
IX. Pseudohypoparathyroidism and Related Disorders 311
X. Signs and Symptoms of Hypocalcemia 410
XI. Biological Findings 417
XII. Treatment 420
XIII. Concluding Remarks 430
References 430
Chapter 4. The Thyroid Gland in Skeletal and Calcium Metabolism 462
I. Introduction 462
II. The Thyroid Hormones: T3 and T4 463
III. Calcitonin 473
IV. Recent Developments 494
References 496
Chapter 5. Paget's Disease of Bone 504
I. Introduction 505
II. Historical Aspects 505
III. Incidence and Epidemiology 505
IV. Histopathology 509
V. Focal Manifestations 520
VI. Complications 533
VII. Metabolic Aspects of Paget's Disease 545
VIII. Systemic Complications and Associated Diseases 560
IX. Drug Treatment 566
X. Etiology 579
References 582
Chapter 6. Disorders of Mineral Metabolism in Malignancy 592
I. Introduction 593
II. Effects of Hypercalcemia 593
III. Clinical Occurrence 600
IV. Pathogenesis of Tumor-Associated Hypercalcemia 605
V. Treatment of Hypercalemia 625
References 637
Chapter 7. Metabolic Bone Disease in Children 648
I. Growth and Development of Skeleton 649
II. Differential Diagnosis of Hypercalcemia 658
III. Differential Diagnosis of Hypocalcemia 673
IV. Normocalcemic Disorders of Mineral Metabolism 687
V. Bone Disease in Disorders of Renal Function 704
References 711
Index 718

Produkt-Details

• Erscheint lt. Verlag: 11.9.2013
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber ► Gesundheit / Leben / Psychologie ► Krankheiten / Heilverfahren
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• ISBN-10: 1-4832-6792-X / 148326792X
• ISBN-13: 978-1-4832-6792-0 / 9781483267920