What Doesn't Kill Us, Makes Us Stronger

Reducing Oxidative Stress & Damage Through Adaptive Stress Responses

Borut Poljsak, Irina Milisav (Autoren)

Buch | Softcover

86 Seiten

2014
Nova Science Publishers Inc (Verlag)
978-1-63463-255-3 (ISBN)

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Oxidative stress, which is caused by endogenous and exogenous reactive-oxygen-species (ROS) formation, may significantly affect health-span and longevity. Endogenous oxidative stress could be attenuated in two ways: by the reduction of ROS formation and by quenching ROS with antioxidants. Numerous results of clinical trials in which individuals received one or more synthetic antioxidants failed to demonstrate conclusive benefits of antioxidant supplementation. Even oral supplementation with endogenous antioxidant enzymes cannot alter the antioxidant balance due to their degradation in the digestive system. Likewise, life-span or health-span is not increased significantly in genetically modified models overexpressing antioxidant enzymes. An alternative approach to attenuate the ROS-induced stress/damage may be through triggering an adaptive stress response in order to increase the endogenous antioxidant and damage repair processes. Moderate stress induced by CR, physical activity or mimetic compounds may induce such activation of endogenous antioxidative defence and cellular repair processes. These processes may increase cellular resistance to subsequent more severe stress and do not seem to interfere with ROS-dependent cellular signalling.

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Erscheint lt. Verlag	1.12.2014
Verlagsort	New York
Sprache	englisch
Maße	155 x 230 mm
Gewicht	196 g
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Anatomie / Neuroanatomie
ISBN-10	1-63463-255-9 / 1634632559
ISBN-13	978-1-63463-255-3 / 9781634632553
Zustand	Neuware