Stroke Genetics

Pankaj Sharma, James F Meschia (Herausgeber)

Buch | Softcover

320 Seiten

2014 | 2013 ed.
Springer London Ltd (Verlag)
978-1-4471-6176-9 (ISBN)

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Over the last decade there has been a substantial increase in our understanding of the genetic basis of common disorders such as stroke. Stroke Genetics is designed to give the reader an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genome-wide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed.

Stroke Genetics benefits from the contribution of renowned experts from throughout the world who have been intimately involved in unraveling the genetic etiology of stroke. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.

Pankaj Sharma, MD, PhD, FRCP Reader & Consultant Neurologist Imperial College London & Hammersmith Hospitals London, UK James F. Meschia, MD Chair, Department of Neurology Mayo Clinic Florida Jacksonville, Florida, USA

Introduction.- Candidate Gene Association Studies in Stroke.- Genome-Wide Association Studies (GWAS).- The Genetics of Cerebral Aneurysms and Other Vascular Malformations.- Intracerebral Hemorrhage and Cerebral Amyloid Angiopathy.- Clinicogenetic and Pathologic Characteristics of CADASIL.- Monogenic Disorder: Fabry Disease.- Stroke-like Episodes in Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS).- Genetics of Sickle Cell Disease and Stroke.- Other Monogenetic Stroke Disorders.- White Matter Disease.- Genetics of Carotid Disease.- Genetics of Cervical Artery Dissection.- Stroke Pharmacogenetics.- Ethical Issues in the Genetics of Complex Disorders.

Erscheint lt. Verlag	20.9.2014
Zusatzinfo	XX, 320 p.
Verlagsort	England
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
Schlagworte	CADASIL • cerebral hemmorhage • Fabry • Genetics • Genome • GWAS • Hypertension • MELAS • Stem Cell • stroke
ISBN-10	1-4471-6176-9 / 1447161769
ISBN-13	978-1-4471-6176-9 / 9781447161769
Zustand	Neuware