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Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials

Buch | Hardcover
VII, 146 Seiten
2014 | 2015
Springer International Publishing (Verlag)
978-3-319-10526-0 (ISBN)

Lese- und Medienproben

Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials - Tony K.L. Kiang, Kyle John Wilby, Mary H.H. Ensom
CHF 74,85 inkl. MwSt

This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested. In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (i.e. chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs.

Introduction.- Pharmacology of Recommended Antimalarial Agents.- Drug Interaction Potential of Antimalarial Drugs Based on Known Metabolic Properties of Antimalarials.- Pharmacokinetic Drug Interactions Affecting Antimalarials.- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Drugs.- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Antimalarials.- Pharmacodynamic Interactions: Clinical Evidence for Combination Therapy, In Vitro Interactions, and In Vivo Interactions.- Limitations, Future Directions, and Conclusions.

Erscheint lt. Verlag 26.11.2014
Zusatzinfo VII, 146 p. 1 illus. in color.
Verlagsort Cham
Sprache englisch
Maße 155 x 235 mm
Gewicht 372 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Mikrobiologie / Infektologie / Reisemedizin
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Studium Querschnittsbereiche Prävention / Gesundheitsförderung
Schlagworte Antimalarial drugs • Interactions • Malaria • Pharmacodynamics • Pharmacokinetics
ISBN-10 3-319-10526-4 / 3319105264
ISBN-13 978-3-319-10526-0 / 9783319105260
Zustand Neuware
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