Neutrophil Gelatinase-Associated Lipocalin

from Laboratory to Clinical Utility

Buch | Hardcover

144 Seiten

2014
Nova Science Publishers Inc (Verlag)
978-1-63117-984-6 (ISBN)

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Acute kidney injury (AKI), defined as an abrupt decrease in renal function over a period of hours to days, is a common complication among hospitalised patients with different acute diseases. Its incidence has been increasing in recent years and is reported to be very high especially in the acute settings. Since clinical signs and symptoms of acute renal damage are not specific, it is difficult to promptly distinguish AKI at the time of patient presentation. Currently the diagnosis of AKI requires serial assessment of laboratory tests over a period of several days, and is based mainly on the evaluation of serum creatinine (sCr) and decrease in urine output as supported by Risk, Injury, Failure, Loss, and End-Stage Kidney Disease (RIFLE) criteria, Acute Kidney Injury Network (AKIN) criteria, and the recent Kidney Disease: Improving Global Outcomes (KDIGO) practice guidelines for AKI. Such a need for repeated sCr evaluations and monitoring of urinary output for too long time after admission could therefore result in a diagnostic delay. With delays in diagnosis, clinicians miss opportunities to start appropriate treatment to minimise damage, and patients incur more severe AKI with subsequent greater risk of developing progression of renal damage leading to chronic kidney disease (CKD), dialysis and increased risk of severe cardiovascular diseases and death.

Preface; Lipocalin: Sequence & Structure Relationships; Common Molecular-Recognition Properties; Biochemistry & Pathophysiology of NGAL; Function of Lipocalin; Lipocalin: Cell Regulation, Cancer Cell Interaction; Urinary versus Plasma NGAL; History of NGAL Assays; Diagnostic Performances of NGAL Assays; Stability & Half-Life: In Vitro, Preanalytical Factors; Reference Ranges & Cut-Off Values for the NGAL Assay; NGAL versus Creatinine; Comparison of NGAL with other New Biomarkers for Kidney Disease; NGAL: A Marker for Acute Kidney Injury; NGAL In Acute Heart Failure Patients; NGAL in Septic Patients; NGAL in Contrast-Induced Nephropathy; NGAL In Hypovolemic Patients; NGAL In Children & Newborns; NGAL As Marker for Prognosis of Acute Kidney Injury; Multi-Markers Approach Including NGAL & other Biomarkers; Index.

Verlagsort	New York
Sprache	englisch
Maße	155 x 230 mm
Gewicht	422 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Nephrologie
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Urologie
ISBN-10	1-63117-984-5 / 1631179845
ISBN-13	978-1-63117-984-6 / 9781631179846
Zustand	Neuware