Glial Cell Development

Basic Principles and Clinical Relevance

Kristjan R. Jessen, William D. Richardson (Herausgeber)

Buch | Hardcover

488 Seiten

2001 | 2nd Revised edition
Oxford University Press (Verlag)
978-0-19-852478-6 (ISBN)

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This is a new edition in the 'Cellular and Molecular Neurobiology' series. The study of glial cell function and development is a major area of research activity in the neurosciences, and these avenues appear to hold the key to understanding, at the molecular level, processes such as myelination and the regulation of axon growth and repair.

This is a new edition in the Cellular and Molecular Neurobiology series. The majority of cells in the nervous system are glial cells. During development, these cells provide growth factors that stimulate the proliferation, migration and survival of neurones and their precursors, and promote and guide axonal growth. In the mature nervous system, glial cells provide insulating myelin sheath around axons and provide metabolic and structural support for neurones. Glial cells also have a major influence on the local response to injury of central nerve tracts and the peripheral nervous system, either promoting, or inhibiting, axonal regrowth and recovery of lost function. This book provides a comprehensive, state-of-the-art overview of research into the development, function and malfunction of glial cells. It offers a compelling insight into how basic research throws light onto diseases and disorders and points the way towards treatments. Teams of internationally renowned experts, all active in research, have contributed chapters.

1. Embryonic and early postnatal development of Schwann cells ; 2. Oligodendrocyte development ; 3. Developmental origins of astrocytes ; 4. Microglia in the developing and mature central nervous system ; 5. The metabolic functions of glial cells ; 6. The role of ion channels and transmitter receptors in glial cell development ; 7. Structure and formation of the node of Ranvier ; 8. Concepts in myelin sheath evolution ; 9. Myelin-specific genes and their mutations in the mouse ; 10. Control of gene expression by oligodendrocytes ; 11. Transcription factors that control Schwann cell development and myelination ; 12. Genetic analysis of gliogenesis in Drosophila ; 13. Astrocytes are dynamic participants in central nervous system development and injury response ; 14. Glial influences on axonal regeneration ; 15. Axon-Schwann cell interactions during peripheral nerve degeneration & regeneration ; 16. The molecular genetics of hereditary demyelinating neuropathies ; 17. Genetic & cellular mechanisms of Schwann cell tumour formation: neurofibromatosis type 1 and neurofibromatosis type 2 ; 18. The neuropathology of Multiple Sclerosis ; 19. Restoring CNS myelin by glial cell transplantation ; 20. Stem cells and their gliogenic potential ; 21. Glial tumours of the CNS

Erscheint lt. Verlag	30.8.2001
Reihe/Serie	Molecular and Cellular Neurobiology Series
Zusatzinfo	8pp colour plates, numerous halftones and line figures
Verlagsort	Oxford
Sprache	englisch
Maße	174 x 248 mm
Gewicht	1080 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
	Naturwissenschaften ► Biologie ► Zoologie
ISBN-10	0-19-852478-1 / 0198524781
ISBN-13	978-0-19-852478-6 / 9780198524786
Zustand	Neuware