Pediatric Dermatology, An Issue of Pediatric Clinics (eBook)

Kara N. Shah (Autor)

eBook Download: PDF | EPUB

2014 | 1. Auflage
100 Seiten
Elsevier Health Sciences (Verlag)
978-0-323-29479-9 (ISBN)

Infos

Educational opportunities for pediatric residents and primary care providers that contribute to increased competence in pediatric dermatology are an important component of improving the quality and efficiency of dermatologic care provided to children and adolescents. The 13 articles that comprise this issue have been selected to capture a significant proportion of the most common skindiseases that are seen in children and adolescents. They are intended to provide practical information on diagnosis and initial management that can be performed by the primary care provider and to provide a framework for allowing for more active involvement by the primary care provider with regards to ongoing management of these conditions. From atopic dermatitis to vitiligo, the pediatric primary care provider is guaranteed to see these conditions in their practice.

Textauszug

Atopic Dermatitis

Sierra Wolter, MD and Harper N. Price, MD∗,     Department of Dermatology, Phoenix Children’s Hospital, 1919 East Thomas Road, Phoenix, AZ 85006, USA

∗Corresponding author. Email: [e-mail]

Atopic dermatitis (AD) is a common chronic inflammatory skin condition characterized by intense pruritus and a waxing and waning course. AD often presents in infancy and childhood and can persist throughout adulthood. The exact cause of AD is unknown, but it likely reflects an interplay between genetic and environmental factors. AD affects up to 20% of children in the United States, and prevalence may be increasing. Treatment can be effective in alleviating symptoms but serves only to manage the disease, not cure it. Appropriate therapy can also prevent significant complications, such as infection, sleep disturbance, behavioral problems, and growth impairment.

Keywords

Atopic dermatitis

Eczema

Pruritus

Diagnosis

Complications

Management recommendations

Key points

• Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by intense pruritus.

• Patients with AD require periodic physician assessment of disease state, comorbidities, and complications.

• Treatment of AD requires a multimodal approach using intensive patient education, antiinflammatories, antibacterial intervention, and psychological support.

Video of Pruritus in atopic dermatitis accompanies this article at http://www.pediatric.theclinics.com/

Overview

Atopic dermatitis (AD) is a common chronic inflammatory skin condition characterized by intense pruritus and a waxing and waning course. This condition most often presents in infancy and childhood and can persist, in one form or another, throughout adulthood. The exact cause of AD is unknown, but it likely reflects an interplay between genetic and environmental factors. AD affects up to 20% of children in the United States, and the prevalence may be increasing.1 Treatment can be very effective in alleviating symptoms but serves only to manage the disease, not cure it. Appropriate therapy can also prevent significant complications, such as infection, sleep disturbance, behavioral problems, and growth impairment.

Epidemiology

Population studies have demonstrated an increasing prevalence of AD throughout the world. In the United States, it affects approximately 10% to 20% of children younger than 18 years, and these numbers are rising. Affected children are more likely to be black, urban, and living in homes with higher education levels.1 As a chronic disease, AD has a significant impact on health care resource utilization, similar to asthma or diabetes. There were an estimated 7.4 million outpatient physician visits for AD during the 7-year-period between 1997 and 2004, amounting to an estimated health care cost of US $364 million to $3.8 billion annually.2,3

Pathophysiology

The exact cause of AD is unknown. However, it is generally agreed that AD results from a combination of genetic and environmental factors. Twin studies support a high rate of concordance; identical twins have a 7-fold increased risk for AD, and fraternal twins have a 3-fold increased risk.4

Healthy skin acts as a barrier to both outside influences and transepidermal water loss. Current theory holds that a genetically compromised barrier allows for penetration of environmental factors (irritants, allergens, and bacteria) with resultant immune dysregulation. A mutation in the filaggrin gene, responsible for an important component of the barrier, can be found in up to 10% of people of European ancestry.5 Filaggrin is an epidermal protein that acts as waterproof “mortar” between keratinocytes in the outermost layer of the skin. Mutations in this protein cause ichthyosis vulgaris and are positively associated with more severe or persistent AD.6

Other prevalent theories of pathogenesis in AD focus on immune dysfunction. One observation in support of the role of immune dysfunction is that many primary immunodeficiency syndromes are characterized by early onset of diffuse eczematous eruptions and are caused by genetic mutations resulting in disruption of various immune functions, such as hyper-immunoglobulin E (IgE) syndrome, severe combined immunodeficiency, Wiskott-Aldrich syndrome, and Omenn syndrome. In the 1980s, a popular theory, termed the “hygiene hypothesis,” emerged in an attempt to explain the fact that atopy tends to affect individuals from developed nations and those in a higher socioeconomic status.7 This hypothesis asserts that the lack of childhood exposure to infectious agents results in an immune response favoring atopy, whereas early exposure to infectious agents triggers a T helper 1 (TH1) response, thus diverting the immune system away from a T helper 2 (TH2) “atopic” response. There is somewhat conflicting data in support of this hypothesis, and in truth, the interplay between TH1 and TH2 is likely more complex than previously thought.8,9 More rigorous studies into causation are needed.

Prevention and prognosis

Many studies have investigated primary prevention strategies and their effect on AD. These studies have examined the effect of early exposure to environmental and dietary factors such peanuts, eggs, soy, and animal dander or early supplementation of probiotics, breast milk, and vitamin D as related to development of AD.10,11 There is currently no convincing evidence that any of these strategies are helpful.

The natural history of AD is variable. Based on population studies, a significant proportion of affected children “outgrow” the disease, as only 1% to 3% of adults are affected.12 Patients with the most severe disease are more likely to have persistent disease.13

Presentation

History

Pruritus, or itch, is defined as an unpleasant sensation that provokes the desire to scratch. A history of pruritus is required to establish the diagnosis of AD. Young infants, who are not yet capable of coordinating scratching behavior, will exhibit fussiness and poor sleep associated with excessive movement or squirming. Older infants and children will scratch and rub at their skin, often incessantly and particularly at night (Video 1).

Most patients manifest symptoms in the first year of life, with the remainder usually presenting before the age of 10 years.14 Parental or sibling history of atopy supports the diagnosis of AD and is a strong risk factor for the development of the disease.15

Physical Examination

In infants, involvement of the face, neck, and extensor extremities (elbows, knees) is characteristic. Infantile eczema on the cheeks can appear more acute with a pseudovesicular or “weepy” appearance (Fig. 1). This condition is often misdiagnosed as impetigo. Persistent, bright red plaques may develop on the cheeks and chin at the time of teething and introduction of solid food, likely related to chronic irritation from saliva and foods. Infants may also have a more diffuse variant, but often with characteristic sparing of the diaper area. Scalp dermatitis is common and linear excoriations are common at this site, even with minimal skin involvement.

Fig. 1 Infantile atopic dermatitis with facial involvement. (Courtesy of Ronald Hansen, MD, Phoenix, AZ.)

With increasing age, children tend to develop the classic flexural patches and plaques on the antecubital and popliteal fossae (Fig. 2). Hand and foot plantar dermatitis is also quite common (Fig. 3). In more severe cases, thickened plaques are seen on the dorsal hands, feet, and knees, often with a lichenified or leathery appearance, with prominent skin lines (Figs. 4–6) Children with darker skin typically have perifollicular hyperpigmented or hypopigmented rough 1- to 2-mm papules that can coalesce into broad, near-diffuse plaques, most prominent on the extensor surfaces (Fig. 7). This can give the skin a “pebbled” or spotty appearance (Fig. 8). This variant is often termed papular eczema. The nummular variant can be seen on the extremities as coin-shaped crusted or exudative plaques.

Fig. 2 Childhood atopic dermatitis with classical involvement of antecubital fossae.

Fig. 3 Palmar involvement in atopic dermatitis.

Fig. 4 Dorsal foot involvement in atopic dermatitis.

Fig. 5 Lichenification in severe atopic...

Produkt-Details

• Erscheint lt. Verlag: 28.4.2014
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pädiatrie
• ISBN-10: 0-323-29479-0 / 0323294790
• ISBN-13: 978-0-323-29479-9 / 9780323294799