Embryonic Stem Cells as a Developmental Model in vitro
Karger, S (Hersteller)
978-3-8055-6975-0 (ISBN)
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A comprehensive overview of the uses of embryonic stem cells in vitro, consisting of articles by leading experts. The first two chapters are dedicated to molecular mechanisms regulating self-renewal and differentiation of ES (embryonic stem) cells and the expression pattern of Oct-4, a key regulator of totipotency during the mammalian life cycle. The articles review the present knowledge of ES cell-derived neurogenesis, adipogenesis, and haemapoiesis on tissue-restricted gene and protein expression. To study developmental aspects of ion channel formation and signalling cascades during early developmental stages, one chapter is devoted to confocal imaging and patch clamp analyses of differentiated cells derived from ES cells. Another article describes the use of ES cells in an in vitro embryotoxicity screening system, and two chapters summarize the attempts to establish pluripotent cell lines from species other than the mouse. One of the most exciting areas of ES cell research is the isolation of pluripotent stem cells of human origin and their possible use in tissue transplantations, a topic addressed in the final chapter of this issue.
Signalling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells, T. Burdon, I. Chambers et al; Oct-4 - lessons of totipotency from embryonic stem cells, M. Pesce, K. Anastassiadis et al; establishment of ionic channels and signalling cascades in the embryonic stem cell-derived primitive endoderm and cardiovascular system, J. Hescheler, B.K. Fleischmann et al; an in vitro pathway from embryonic stem cells to neurons and glia, D.I. Gottlieb and J.E. Huettner; embryonic stem cell-derived andipogenesis, C. Dani; embryonal stem cell-derived haematopoiesis, N. Hole; induction of cellular differentiation by retinoic acid in vitro, J. Rohwedel, K. Guan and A.M. Wobus; embryotoxicity screening using embryonic stem cells in vitro - correlation to in vivo teratogenicity, G. Scholz, I. Pohl et al; chicken embryonic stem cells and transgenic strategies, B. Pain, P. Chenevier and J. Samarut; establishment of pluripotent cell lines from vertebrate species - present status and future prospects, K. Prelle, I.M. Vasiliev et al; can exogenous stem cells be used in transplantation? K.R. Boheler and M.Y. Fiszman; embryonic stem cells - an exciting find for basic research and tissue engineering, but also an ethical dilemma? H.-W. Denker.
| Zusatzinfo | 37 figs., 9 in color, 9 tab. |
|---|---|
| Verlagsort | Basel |
| Sprache | englisch |
| Maße | 210 x 280 mm |
| Einbandart | Paperback |
| Themenwelt | Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie | |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| Technik ► Umwelttechnik / Biotechnologie | |
| ISBN-10 | 3-8055-6975-0 / 3805569750 |
| ISBN-13 | 978-3-8055-6975-0 / 9783805569750 |
| Zustand | Neuware |
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