Drug Discovery and Development, 2 Volume Set
Wiley-Interscience (Verlag)
978-0-471-39846-2 (ISBN)
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This two-volume set provides a full account of the entire sequence of drug development, from conceptualizing the drug, creating a library of candidates, and conducting clinical trials, to optimizing the synthetic route, marketing the drug, and developing delivery methods. Comprehensive in scope, the set bridges the gap between medicinal and process chemistry.
Discussion includes the discovery of agents for the treatment and management of bacterial infections, Parkinson's disease, psoriasis, ulcers and stomach pain, atopic dermatitis, asthma, and cancer. Case studies examine the discovery of erythromycin analogs (antibiotics), Tagamet, and Ultiva (remifentanil). Full chapters are devoted to combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics. Industrial chemists, biologists, biochemists, and business people in the pharmaceutical industry will all benefit from this authoritative reference. The first volume of this set thoroughly describes conceptualizing a drug, creating a library of candidates for testing, screening those candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and revising the drug as necessary.
The second volume describes optimizing the synthetic route; manufacturing, outsourcing, and marketing the drug, including coloring; and developing delivery methods.
Mukund S. Chorghade, PHD, is President of Chorghade Enterprises, Inc., a firm based in Natick, Massachusetts that provides consultations to major pharmaceutical companieson collaborations with worldwide academic, government, and industrial laboratories; European technology-based companies; process reengineering; and project management of technology transfer.
Bioactive Molecules in Medicinal Plants: A Perspective on their Therapeutic Action / S C Taneja, G N Qazi Natural Products as an Inspiration for the Discovery of New High-Throughput Chemical Synthesis Tools / Steven V Ley, Ian R Baxendale, Deborah A Longbottom, Rebecca M Myers
Insulin Sensitizers: Emerging Therapeutics / Braj B Lohray, Vidya B Lohray
Criteria for Industrial Readiness of Chiral Catalysis Technology for the Synthesis of Pharmaceuticals / Raymond McCague, Ian C Lennon
Enantioselective Synthesis of Propargyl Alcohols as Multifunctional Synthons / J S Yadav, S Chandrasekhar
Carbohydrates: From Chirons to Mimics / G V M Sharma, Palakodety Radha Krishna
Meeting the Challenges of Process Development and Scale-up of Active Pharmaceutical Ingredients / Yatendra Kumar, B Vijayaraghavan
Importance of Polymorphs and Salts in the Pharmaceutical Industry / Bipin Pandey, Vidya B Lohray, Braj B Lohray
Role of Outsourcing in Drug Manufacture / Peter Pollak
Regulation-Driven Process Chemistry / Shrikant V Kulkarni
Chemical Process Scale-Up Tools: Mixing Calculations, Statistical Design of Experiments, and Automated Laboratory Reactors / Andrei A Zlota
Library Quality Metrics / Richard L Wife, Johan Tijhuis
Tying a GABA from Copenhagen to Chicago: The Chemistry of Tiagabine / Mukund S Chorghade, Mahendra N Deshpande, Richard J Pariza Building Contract Research Businesses Based on Integration of
Basic and Applied Research / Mukund S Chorghade, Mukund K Gurjar, C V Ramana, Sreenivas Punna
Principles and Practice of Clinical Drug Development / Colin Scott
Index.
Volume 1. Drug discovery [chapters 1-16]
Volume 2. Drug development [chapters 17-31].
From patent to prescription : paving the perilous path to profit / Richard J. Pariza
Medicinal chemistry in the new millennium : a glance into the future / Paul W. Erhardt
Contemporary drug discovery / Lester A. Mitscher, Apurba Dutta
Combinatorial chemistry in the drug discovery process / Ian Hughes
Parallel solution-phase synthesis / Norton P. Peet, Hwa-Ok Kim
Timing of analog research in medicinal chemistry / János Fischer, Anikó Gere
Possible alternatives to high-throughput screening / Camille G. Wermuth
Proteomics and drug discovery / Susan Dana Jones, Peter G. Warren
Using drug metabolism databases during drug design and development / Paul W. Erhardt
Discovery of the antiulcer drug Tagamet / C. Robin Ganellin
Discovery of potent nonpeptide vasopressin receptor antagonists / Bruce E. Maryanoff
Discovery and development of the ultrashort-acting analgesic Remifentanil / Paul L. Feldman
Discovery and development of Nevirapine / Karl Grozinger, John Proudfoot, Karl Hargrave
Applications of nuclear imaging in drug discovery and development / John W. Babich, William C. Eckelman
Polymeric sequestrants as nonabsorbed human therapeutics / Pradeep K. Dhal, Chad C. Huval, S. Randall Holmes-Farley
Botanical immunomodulators and chemoprotectants in cancer therapy / Bhushan Patwardhan, Manish Gautam, Sham Diwanay
Bioactive molecules in medicinal plants : a perspective on their therapeutic action / S.C. Taneja, G.N. Qazi
Natural products as an inspiration for the discovery of new high-throughput chemical synthesis tools / Steven V. Ley, Ian R. Baxendale, Deborah A. Longbottom, Rebecca M. Myers
Insulin sensitizers : emerging therapeutics / Braj B. Lohray, Vidya B. Lohray
Criteria for industrial readiness of chiral catalysis technology for the synthesis of pharmaceuticals / Raymond McCague, Ian C. Lennon
Enantioselective synthesis of propargyl alcohols as multifunctional synthons / J.S. Yadav, S. Chandrasekhar Carbohydrates : from chirons to mimics / G.V.M. Sharma, Palakodety Radha Krishna
Meeting the challenges of process development and scale-up of active pharmaceutical ingredients / Yatendra Kumar, B. Vijayaraghavan
Importance of polymorphs and salts in the pharmaceutical industry / Bipin Pandey, Vidya B. Lohray, Braj B. Lohray
Role of outsourcing in drug manufacture / Peter Pollak
Regulation-driven process chemistry / Shrikant V. Kulkarni
Chemical process scale-up tools : mixing calculations, statistical design of experiments, and automated laboratory reactors / Andrei A. Zlota
Library quality metrics / Richard L. Wife, Johan Tijhuis
Tying a GABA from Copenhagen to Chicago : the chemistry of Tiagabine / Mukund S. Chorghade, Mahendra N. Deshpande, Richard J. Pariza
Building contract research businesses based on integration of basic and applied research / Mukund S. Chorghade, Mukund K. Gurjar, C.V. Ramana, Sreenivas Punna
Principles and practice of clinical drug development / Colin Scott
| Erscheint lt. Verlag | 14.9.2007 |
|---|---|
| Reihe/Serie | Drug Discovery and Development. 2 Volume Set | 1.10 |
| Sprache | englisch |
| Maße | 188 x 262 mm |
| Gewicht | 971 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Laboratoriumsmedizin |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
| Naturwissenschaften ► Chemie | |
| ISBN-10 | 0-471-39846-2 / 0471398462 |
| ISBN-13 | 978-0-471-39846-2 / 9780471398462 |
| Zustand | Neuware |
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