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Behçet's Disease

From Genetics to Therapies

Yoshiaki Ishigatsubo (Herausgeber)

Buch | Hardcover
176 Seiten
2014 | 2015 ed.
Springer Verlag, Japan
978-4-431-54486-9 (ISBN)

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This book, besides reviewing basic and clinical aspects of Behçet's disease, covers the latest findings, including genetic studies and treatment with biologics for the disease.
Although the cause of Behçet's disease is still unknown, it is well known that genetic factors, such as HLA-B51, are involved in its development. Recently, novel susceptibility loci including IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 have been identified, providing new insights into the pathogenesis of the disease. In addition to basic research, the beneficial efficacy of anti-TNF-alpha monoclonal antibodies has also been suggested for not only uveitis associated with the disease but also other subtypes of the disease such as entero-, vasculo-, and neuro- Behçet's disease. Behçet's Disease:  From Genetics to Therapies  provides essential information both for basic researchers working in the fields of immunology, inflammation, and genetics, and for clinical physicians who are interested in Behçet's disease, such as ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.​

Yoshiaki Ishigatsubo Professor and Chairman, Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine The president, Behcet's Disease Research Committee, Ministry of Health, Labor, and Welfare, Japan

1. Overview.- 2. The Immunopathology of Behcet’s Disease.- 3. Genetics.- 4. Ocular Involvement.- 5. Vascular Involvement of Behçet’s Disease.- 6. Neurological Involvement.- 7. Gastrointestinal Involvement.- 8. Mucocutaneous Manifestations.- 9. Perspective​.

Zusatzinfo 31 Illustrations, color; 7 Illustrations, black and white; IX, 176 p. 38 illus., 31 illus. in color.
Verlagsort Tokyo
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Augenheilkunde
Medizin / Pharmazie Medizinische Fachgebiete Dermatologie
Medizinische Fachgebiete Innere Medizin Gastroenterologie
Medizinische Fachgebiete Innere Medizin Rheumatologie
Medizin / Pharmazie Medizinische Fachgebiete Mikrobiologie / Infektologie / Reisemedizin
Schlagworte anti-TNF-alpha antibodies • Autoimmune • Uveitis
ISBN-10 4-431-54486-0 / 4431544860
ISBN-13 978-4-431-54486-9 / 9784431544869
Zustand Neuware
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