DNA Topoisomerases and Cancer

Buch | Softcover

443 Seiten

2013
Springer-Verlag New York Inc.
978-1-4614-2963-0 (ISBN)

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DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include basic biochemical and structural reviews for the cancer-relevant topoisomerases. It will describe how topoisomerase dysfunctions can damage the genome and increase the risk of cancers, and the involvement of topoisomerases in programmed cell death. The book will also present the various topoisomerase inhibitors in clinical use and development and their molecular and cellular mechanisms of action.

Introduction and Historical Perspective.- Human DNA topoisomerase I: Structure, Enzymology and Biology.- Mitochondrial topoisomerases.- Structure and mechanism of eukaryotic type IIA topoisomerases.- Essential functions of topoisomerase III in the nucleus and mitochondria.- DNA topoisomerase I and illegitimate recombination.- Topoisomerase-induced DNA damage.- Topoisomerases and carcinogenesis: Topo III and BLM.- Topoisomerase inhibitors: a paradigm for interfacial inhibitors.- Topoisomerase I inhibitors: chemical biology.- Topoisomerase II inhibitors: chemical biology.- Topoisomerase I inhibitors: current use and prospects.- Topoisomerase II inhibitors: current use and prospects.- Transcription stress by camptothecin: mechanism and implication for the drug antitumor activity.- Mechanism regulating cellular responses to DNA topoisomerase I-targeted agents.- Tyrosyl-DNA-phosphodiesterase.- Ubiquitin and ubiquitin-like proteins in repair of topoisomerase-mediated DNA damage.- Repair of topoisomerase II-mediated DNA damage: fixing DNA damage arising from a protein covalently trapped on DNA.- Topoisomerases and Apoptosis.- Index.

Reihe/Serie	Cancer Drug Discovery and Development
Zusatzinfo	49 Illustrations, color; 16 Illustrations, black and white; XI, 443 p. 65 illus., 49 illus. in color.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Studium
Schlagworte	Antigens • camptothecins • transcriptional stress • Tyrosyl-DNA-Phosphodiesterase • Ubiquitin
ISBN-10	1-4614-2963-3 / 1461429633
ISBN-13	978-1-4614-2963-0 / 9781461429630
Zustand	Neuware