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Axonal Regeneration in the Mammalian Central Nervous System

A Critique of Hypotheses

Dorothy E. Oorschot, David G. Jones (Autoren)

Buch | Softcover

VII, 121 Seiten

1990
Springer Berlin (Verlag)
978-3-540-51757-3 (ISBN)

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This state-of-the-art review links the experimental data into a cohesive and critical account of CNS regeneration. Research findings are discussed in terms of their relevance to one (or more) of thirteen hypotheses concerned with regeneration in the mammalian CNS. Research findings reviewed include: regeneration in developing mammals and in submammalian vertebrates, the use of transplants and/or pharmacological treatments, in vitro studies on neurotrophic and neurite promoting factors and their potential relevance to CNS regeneration in vivo, and in vitro studies on the types of glial cells that may be responsible for enhancing or suppressing axonal re-growth.

1 Hypotheses Concerned with Regeneration in the Mammalian Central Nervous System.- 1.1 Introduction.- 1.2 Histopathological Response to Trauma.- 1.3 Successful Regeneration of Some Neurons in the Mammalian CNS.- 1.4 Hypotheses to Explain the Limited Regenerative Capacity of CNS Neurons.- 2 In Vivo Experimental Approaches to Hypotheses Concerned with Regeneration in the Mammalian CNS.- 2.1 Introduction.- 2.2 Submammalian Vertebrates.- 2.3 Developmental Events in Mammals.- 2.4 Morphological and Biochemical Assessment of Regeneration in Mammals.- 2.5 The Use of Transplants.- 2.6 Pharmacological Approaches.- 2.7 Conclusions.- 3 In Vitro Experimental Approaches to Hypotheses Concerned with Regeneration in the Mammalian CNS.- 3.1 Introduction.- 3.2 The Role of the Microenvironment - Neuronotrophic Factors.- 3.3 The Role of the Microenvironment - The Substrate and Substrate-Bound Neurite Promoting Factors.- 3.4 The Role of the Microenvironment - Humoral Neurite-Promoting Factors.- 3.5 The Role of the Microenvironment - The Non-neuronal Cells.- 4 Conclusions.- References.

Erscheint lt. Verlag	20.4.1990
Reihe/Serie	Advances in Anatomy, Embryology and Cell Biology
Zusatzinfo	VII, 121 p. 18 illus.
Verlagsort	Berlin
Sprache	englisch
Maße	170 x 242 mm
Gewicht	295 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Anatomie / Neuroanatomie
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zoologie
Schlagworte	Gliazellen • nervous system • neurons • Regeneration • Säugetiere • Transplantation • Zentralnervensystem
ISBN-10	3-540-51757-X / 354051757X
ISBN-13	978-3-540-51757-3 / 9783540517573
Zustand	Neuware