Transgenerational Epigenetics
Academic Press Inc (Verlag)
978-0-12-405944-3 (ISBN)
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Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms including DNA methylation, histone modifications or RNA and the effects can persist for multiple generations.
This book examines the evolution of epigenetic inheritance, its expression in animal and plant models, and how human diseases, such as metabolic disorders and cardiovascular diseases, appear to be affected by transgenerational epigenetic inheritance. It discusses clinical interventions in transgenerational epigenetic inheritance that may be on the horizon to help prevent diseases before the offspring are born, or to reduce the severity of diseases at the very earliest stages of development in utero, and current controversies in this area of study, as well as future directions for research.
Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O’Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.
1. Transgenerational Epigenetics 2. Historical Perspective of Transgenerational Epigenetics 3. Epidemiology of Transgenerational Epigenetics 4. Metastable Epiallels 5. Paramutations 6. Epigenetic Silencing of Transgenes 7. Epigenetic Inheritance of Repeat Sequences 8. Histone-mediated Transgenerational Epigenetics 9. Heritable Generational Effects Through RNA 10. Animal Models of Transgenerational Epigenetic Effects 11. Plant Models of Transgnerational Epigenetic Inheritance 12. Transgenerational Epigenetic Effects in Plants 13. Maternal Epigenetic Inheritance 14. Paternal Epigenetic Inheritance 15. Evolution of Transgenerational Epigenetic Inheritance 16. Heritable Epigenetics Over Multiple Generations 17. Maternal Stress Effects on Transgenerational Epigenetics 18. Preimplantation Environment and Epigenetic Transgenerational Inheritance 19. Transgenerational Epigenetic Inheritance and Human Disease 20. Environmental Transgenerational Epigenetic Effects 21. Transgenerational Epigenetics of Endocrine Disruptors 22. Effects of Transgenerational Epigenetics on Longevity 23. Transgenerational Epigenetic Effects of an Environmental Enrichment on Memory Formation 24. Dietary Effects on Transgenerational Epigenetic Inheritance 25. Clinical Applications of Transgenerational Epigenetics 26. Transgenerational Epigenetics: Current Controversies 27. Future Directions of Transgenerational Epigenetic Research
| Verlagsort | San Diego |
|---|---|
| Sprache | englisch |
| Maße | 216 x 276 mm |
| Gewicht | 1450 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| Naturwissenschaften ► Biologie ► Ökologie / Naturschutz | |
| ISBN-10 | 0-12-405944-9 / 0124059449 |
| ISBN-13 | 978-0-12-405944-3 / 9780124059443 |
| Zustand | Neuware |
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