Stereoselective Syntheses of Tetrahydropyrans
Applications to the Synthesis of (+)-Leucascandrolide A, (+)-Dactylolide and (±)-Diospongin A
Seiten
2014
|
2014
Springer International Publishing (Verlag)
978-3-319-04461-3 (ISBN)
Springer International Publishing (Verlag)
978-3-319-04461-3 (ISBN)
In his book, Kiyoun Lee describes his studies into tandem and organocatalytic oxa-conjugate addition reactions for the synthesis of complex tetrahydropyrans. These reactions are applicable to a range of substrates and proceed with excellent stereoselectivity.
In his thesis, Kiyoun Lee describes his studies into tandem and organocatalytic oxa-conjugate addition reactions for the synthesis of complex tetrahydropyrans (THP). Readers gain insight into the new methods Lee employs for the synthesis of biologically interesting natural products including (+)-leucascandrolide A, (+)-dactylolide, and (±)diospongin A. The reactions Lee investigates are applicable to a broad range of substrates and proceed with excellent stereoselectivity. Moreover, the methodologies allow the synthesis of a wide range of THP-containing compounds. The development of reactions, such as those discussed by Lee, has the potential to impact natural product synthesis, pharmaceutical development and chemical biology.
In his thesis, Kiyoun Lee describes his studies into tandem and organocatalytic oxa-conjugate addition reactions for the synthesis of complex tetrahydropyrans (THP). Readers gain insight into the new methods Lee employs for the synthesis of biologically interesting natural products including (+)-leucascandrolide A, (+)-dactylolide, and (±)diospongin A. The reactions Lee investigates are applicable to a broad range of substrates and proceed with excellent stereoselectivity. Moreover, the methodologies allow the synthesis of a wide range of THP-containing compounds. The development of reactions, such as those discussed by Lee, has the potential to impact natural product synthesis, pharmaceutical development and chemical biology.
Introduction.- Significance.- General Approaches to the Synthesis of Substituted Tetrahydropyrans.- Stereoselective Synthesis of Tetrahydropyrans via Tandem and Organocatalytic Oxa-Conjugate Addition Reactions.- Introduction.- Preliminary Study.- Result and Discussion.- Synthesis of 4-Hydroxy-2,6-cis-Tetrahydropyrans via Tandem Cross-Metathesis/Thermal SN2' Reaction.
| Erscheint lt. Verlag | 24.3.2014 |
|---|---|
| Reihe/Serie | Springer Theses |
| Zusatzinfo | XIX, 184 p. 256 illus., 12 illus. in color. |
| Verlagsort | Cham |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 473 g |
| Themenwelt | Medizin / Pharmazie ► Pharmazie |
| Naturwissenschaften ► Chemie ► Organische Chemie | |
| Naturwissenschaften ► Chemie ► Technische Chemie | |
| Technik | |
| Schlagworte | (+)-Dactylolide • (±)-Diospongin A • Gem-disubstituent Effect • (+)-Leucascandrolide A • Tandem and Organocatalytic Oxa-conjugate Addition • Tandem Cross-metathesis/thermal SN2' • Tandem Cross-metathesis/thermal SN2′ • Tetrahydropyran |
| ISBN-10 | 3-319-04461-3 / 3319044613 |
| ISBN-13 | 978-3-319-04461-3 / 9783319044613 |
| Zustand | Neuware |
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