Molecular Pathology of Alzheimer's Disease

Rudy Castellani, George Perry (Autoren)

Buch | Softcover

91 Seiten

2013
Morgan & Claypool Publishers (Verlag)
978-1-61504-638-6 (ISBN)

Artikel merken

Alzheimer’s Disease is characterized pathologically by two principal hallmark lesions: the senile plaque and the neurofibrillary tangle. Since the identification of each over 100 years ago, the major protein components have been elucidated. This has led in turn to the elaboration of metabolic cascades involving amyloid-? production in the case of the senile plaque, and phosphorylated-tau protein in the case of the neurofibrillary tangle. The pathogenesis and histogenesis of each have been the source of extensive investigation and some controversy in recent years, as both cascades have been implicated in the pathogenesis of Alzheimer’s Disease, relied upon in the diagnostic criteria for Alzheimer’s Disease at autopsy, and targeted for therapeutic intervention. With the accumulation of data and expansion of knowledge of the molecular biology of Alzheimer’s Disease, it appears that the enthusiasm for successful intervention has been premature. In this book, we detail the discovery and characterization of the major pathological lesions, their associated molecular biology, their relationship to clinical disease, and potential fundamental errors in understanding that may be leading scientific investigators in unintended directions.

Introduction
Plaques
Neurofibrillary Degeneration
Complexities
Synopsis and Conclusion
References
Author Biographies

Erscheint lt. Verlag	30.10.2013
Reihe/Serie	Colloquium Series on Neurobiology of Alzheimer's Disease
Verlagsort	San Rafael
Sprache	englisch
Maße	191 x 235 mm
Gewicht	190 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Anatomie / Neuroanatomie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Naturwissenschaften ► Biologie ► Humanbiologie
ISBN-10	1-61504-638-0 / 1615046380
ISBN-13	978-1-61504-638-6 / 9781615046386
Zustand	Neuware