Gastric Cytoprotection

A Clinician’s Guide

Daniel Hollander, Andrzej S. Tarnawski (Herausgeber)

Buch | Softcover

220 Seiten

2013 | Softcover reprint of the original 1st ed. 1989
Springer-Verlag New York Inc.
978-1-4684-5699-8 (ISBN)

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Gastric secretions contain hydrogen ions at a concentration that is more than one million times higher than their intracellular concentration. This phenomenal gradient as well as the demonstrated ability of gastric juice to digest tissues has motivated clinicians and investigators alike to emphasize acid secretion and acid ablation in studying the pathogenesis and therapy of peptic ulcer disease. Conse quently, over the past 150 years, we have made considerable progress in under standing the mechanisms and regulation of acid secretion by the stomach. Not surprisingly, therapy for both peptic disease and mucosal injury has also been predominantly directed at either neutralizing acid or suppressing its production. During the past 10 years, attention has been focused on factors other than acid in the genesis and therapy of ulcer disease. Work done worldwide demon strated that acid hypersecretion is not a common event in peptic ulcer disease. Therefore, we began realizing that factors other than acid secretion may be important in the genesis of ulcer disease or in gastroduodenal mucosal damage. In addition, new physiological information has established that the gas troduodenal mucosa is normally protected by a complex series of events includ ing mucus and bicarbonate secretion, cell renewal, surface mucosal restitution, and preservation of the microvasculature and mucosal proliferative zone.

I. Cytoprotection for the Clinician.- 1 Cytoprotection: Historical Perspective.- 2 Acid Hypersecretion: Important Factor or Innocent Bystander?.- 3 Pathomorphology of Gastric Mucosal Injury.- II Defensive Mechanisms of the Stomach.- 4 Mechanisms of Mucosal Protection.- 5 Mucus Secretion.- 6 Bicarbonate Secretion and the Alkaline Microclimate.- 7 Epithelial Cell Renewal.- 8 Gastric Blood Flow and Mucosal Defense.- III. Cytoprotective Therapy.- 9 Cytoprotective Therapy: Prostaglandins.- 10 The Role of Nutrient Essential Fatty Acids in Gastric Mucosal Protection.- 11 Gastroprotection by Nonprostaglandin Substances.

Zusatzinfo	XV, 220 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	152 x 229 mm
Themenwelt	Medizin / Pharmazie ► Gesundheitswesen
	Medizinische Fachgebiete ► Chirurgie ► Viszeralchirurgie
	Medizinische Fachgebiete ► Innere Medizin ► Gastroenterologie
	Medizinische Fachgebiete ► Innere Medizin ► Hepatologie
ISBN-10	1-4684-5699-7 / 1468456997
ISBN-13	978-1-4684-5699-8 / 9781468456998
Zustand	Neuware