Cholinesterases and Anticholinesterase Agents

Media-Kombination

XVI, 1220 Seiten | Ausstattung: Softcover

2013 | 1. Softcover reprint of the original 1st ed. 1963
Springer Berlin
978-3-642-99877-5 (ISBN)

Artikel merken

Although the anticholinesterase (anti-ChE) agents have only limited applica tions in therapy, and from the viewpoint of practical significance they are more appropriately classified as toxic compounds or insecticides than as drugs, in their capacity of pharmacological tools they have few equals. The concept of neuro humoral transmission was originally established largely from experiments in which physostigmine, or eserine, was employed to protect acetylcholine (ACh), the trans mitter of the cholinergic nerves, from rapid hydrolytic destruction by acetyl cholinesterase (AChE) and other cholinesterases (ChE's). Since then, a great num ber of additional reversible and irreversible anti-ChE agents also have been indis pensable in studies of synaptic and neuroeffector transmission, and of other physiological processes. At the same time, there is practically no other class of compounds for which a mechanism of pharmacological action can be described in such concrete biochemical and physiological terms. Consequently, it is not sur prising that a huge literature has developed on these several closely interdependent topics. The assembling anrl proper correlation of this material for the present volume has taken the collaborative efforts of over two dozen . investigators. It iR believed that their contributions to this end will prove invaluable to future in vestigators in providing a ready, inclusive source of established information, in defining areas where further studies are indicated, and in preventing unnecessary duplication of past work. How well these aims have been accomplished will be for time and the reader to judge.

Erscheint lt. Verlag	25.11.2013
Reihe/Serie	Handbook of Experimental Pharmacology
Mitarbeit	Stellvertretende Herausgeber: George B. Koelle
Zusatzinfo	XVI, 1220 p. In 2 volumes, not available separately.
Verlagsort	Berlin
Sprache	englisch
Maße	170 x 244 mm
Gewicht	1966 g
Themenwelt	Medizin / Pharmazie ► Allgemeines / Lexika
Themenwelt	Medizin / Pharmazie ► Pharmazie ► PTA / PKA
Schlagworte	Acetylcholin • Drugs • Insects • pharmacology • therapy
ISBN-10	3-642-99877-1 / 3642998771
ISBN-13	978-3-642-99877-5 / 9783642998775
Zustand	Neuware