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Pathogenicity Islands and the Evolution of Pathogenic Microbes

Volume I

J. Hacker, J.B. Kaper (Herausgeber)

Buch | Hardcover

XVII, 234 Seiten

2002 | 2002
Springer Berlin (Verlag)
978-3-540-42681-3 (ISBN)

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It has been known for a number of years that not only pathogenicity islands but also plasmids and bacteriophages are able to carry genes whose products are involved in pathogenic processes. Accordingly, such elements and their products play an important role in pathogenesis due to the intestinal E. coli as well due to Shigellae. Another interesting aspect which is reflected in different articles is that genomes evolve by acquisition of new pieces of DNA following gene transfer, but also by genome reduction. Different mechanisms include the deletion of sequences or the elimination of functions by the accumulation of point mutations or rearrangements.

List of Contents.- Evolution of Prokaryotic Genomes.- Extraintestinal Escherichia coli as a Model System for the Study of Pathogenicity Islands.- Pathogenicity Islands of Intestinal E. coli.- Pathogenicity Islands of Shigella.- Pathogenicity Islands and Host Adaptation of Salmonella Serovars.- Plasmids and Pathogenicity Islands of Yersinia.- Genomic Organization of LPS-Specific Loci.- Genomic Structure of Capsular Determinants.- Genome Plasticity in Pathogenic and Nonpathogenic Enterobacteria.- Phylogenetic Relationships and Virulence Evolution in the Genus Bordetella.- Pathogenicity Islands and PAI-Like Structures in Pseudomonas Species.

From the reviews:

"In addition to classic mutational events, a highly successful strategy of generating genetic diversity in bacteria is the acquisition of genomic islands. ... This compendium ... features an international assembly of authors including W. Arber (Basel) giving a lucid introduction into the evolution of prokaryotic genomes. The two-volume work provides a comprehensive overview of the current state of knowledge on PAIs and other mobile virulence determinants in bacterial as well as fungal pathogens of humans and plants." (Susanne Rohrer, BioWorld, Issue 6, 2002)

Erscheint lt. Verlag	1.3.2002
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	XVII, 234 p. 23 illus.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	550 g
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
Themenwelt	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	Bacteria • bordetella • DNA • enterobacteria • Escherichia coli • genes • gene transfer • microbe • pathogenesis • Pseudomonas • shigella • yersinia
ISBN-10	3-540-42681-7 / 3540426817
ISBN-13	978-3-540-42681-3 / 9783540426813
Zustand	Neuware