Immune Mechanisms of Hypertension
Seiten
2013
Morgan & Claypool Publishers (Verlag)
978-1-61504-582-2 (ISBN)
Morgan & Claypool Publishers (Verlag)
978-1-61504-582-2 (ISBN)
Provides a history of the early studies linking immune system function with hypertension and an overview of the large number of studies published in the past decade. The major focus is on the components of the innate and adaptive immune systems for which there is considerable evidence of their contributions to blood pressure control.
In the vast majority of patients, hypertension has no identifiable cause. Moreover, despite decades of discovery and therapeutic development, approximately only half of the hypertensive patients are achieving clinically recommended blood pressure control. For these reasons, there has been continued interest in studying the factors that underlie the pathogenesis of hypertension. One area of research that has garnered significant attention is the potential link between immune system activation and blood pressure. Several lines of evidence, dating back several decades, support the concept for this association. This monograph gives a history of the early studies linking immune system function with hypertension and an overview of the large number of studies published in the past decade. The major focus is on the components of the innate and adaptive immune systems for which there is considerable evidence of their contributions to blood pressure control.
In the vast majority of patients, hypertension has no identifiable cause. Moreover, despite decades of discovery and therapeutic development, approximately only half of the hypertensive patients are achieving clinically recommended blood pressure control. For these reasons, there has been continued interest in studying the factors that underlie the pathogenesis of hypertension. One area of research that has garnered significant attention is the potential link between immune system activation and blood pressure. Several lines of evidence, dating back several decades, support the concept for this association. This monograph gives a history of the early studies linking immune system function with hypertension and an overview of the large number of studies published in the past decade. The major focus is on the components of the innate and adaptive immune systems for which there is considerable evidence of their contributions to blood pressure control.
Introduction
The Immune System: Key Players
Immune System Activation and Human Hypertension
Long-Term Blood Pressure Control: Role of the Kidneys
Early Animal Experiments on Immune Function and Hypertension in Animals
Cytokines and Inflammatory Mediators in Experimental Hypertension
Innate Immune Contributions to Hypertension
Adaptive Immune Contributions to Hypertension: Role of T Cells
Adaptive Immune Contributions to Hypertension: Autoimmunity
Mechanisms and Perspectives
References
Author Biography
| Erscheint lt. Verlag | 30.9.2013 |
|---|---|
| Reihe/Serie | Colloquium Series on Integrated Systems Physiology: From Molecule to Function |
| Verlagsort | San Rafael |
| Sprache | englisch |
| Maße | 191 x 235 mm |
| Gewicht | 177 g |
| Themenwelt | Studium ► 1. Studienabschnitt (Vorklinik) ► Anatomie / Neuroanatomie |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie | |
| Naturwissenschaften ► Biologie ► Humanbiologie | |
| ISBN-10 | 1-61504-582-1 / 1615045821 |
| ISBN-13 | 978-1-61504-582-2 / 9781615045822 |
| Zustand | Neuware |
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