Opioids I

Buch | Softcover

XXXVII, 815 Seiten

2011 | 1. Softcover reprint of the original 1st ed. 1993
Springer Berlin (Verlag)
978-3-642-77462-1 (ISBN)

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In 1957 Otto SCHAUMANN, one of the pionieers in pharmacological research on morphine and the first to prepare synthetic opiates, presented a mono graph entitled "Morphin und morphiniihnliche Verbindungen" as Volume 12 of the Handbook of Experimental Pharmacology. Now, 35 years later, we are publishing in the same series a new comprehensive volume covering the present status of opioid research. Since that time the topic has expanded enormously. The identification of opioid receptors and the detection of their endogenous ligands were landmarks which opened a new era in opioid research and fertilized the entire field of neurobiology. The rapid develop ment of this field is illustrated in the figure, which represents the number of papers published on opioid research since 1970 (searches performed on the MEDLINE data base). 3000 Vl

S. J. Watson wurde in den Midlands geboren, lebt in London und hat viele Jahre für den staatlichen britischen Gesundheitsdienst (NHS) gearbeitet. Sein erster Roman "Ich. Darf. Nicht. Schlafen." wurde aus dem Stand zu einem internationalen Mega-Bestseller, der in über 40 Ländern erscheint und in Hollywood verfilmt wird.

Section A: Opioid Receptors/Multiplicity.- 1 Opioid Receptor Multiplicity: Isolation, Purification, and Chemical Characterization of Binding Sites.- 2 Expression Cloning of cDNA Encoding a Putative Opioid Receptor.- 3 Characterization of Opioid-Binding Proteins and Other Molecules Related to Opioid Function.- 4 Use of Organ Systems for Opioid Bioassay.- 5 Anatomical Distribution of Opioid Receptors in Mammalians: An Overview.- 6 Opioid Receptor Regulation.- 7 Multiple Opioid Receptors and Presynaptic Modulation of Neurotransmitter Release in the Brain.- 8 Opioid Receptor-G Protein Interactions: Acute and Chronic Effects of Opioids.- 9 Opioid Receptor-Coupled Second Messenger Systems.- 10 Allosteric Coupling Among Opioid Receptors: Evidence for an Opioid Receptor Complex.- Section B: Chemistry of Opioids with Alkaloid Structure.- 11 Chemistry of Nonpeptide Opioids.- 12 Selective Nonpeptide Opioid Antagonists.- 13 Presence of Endogenous Opiate Alkaloids in Mammalian Tissues.- Section C: Opioid Peptides.- 14 Regulation of Opioid Peptide Gene Expression.- 15 Regulation of Pituitary Proopiomelanocortin Gene Expression.- 16 Molecular Mechanisms in Proenkephalin Gene Regulation.- 17 Proopiomelanocortin Biosynthesis, Processing and Secretion: Functional Implications.- 18 Biosynthesis of Enkephalins and Proenkephalin-Derived Peptides.- 19 Prodynorphin Biosynthesis and Posttranslational Processing.- 20 Anatomy and Function of the Endogenous Opioid Systems.- 21 Atypical Opioid Peptides.- 22 Opioid Peptide Processing Enzymes.- 23 Peptidase Inactivation of Enkephalins: Design of Inhibitors and Biochemical, Pharmacological and Clinical Applications.- 24 Coexistence of Opioid Peptides with Other Neurotransmitters.- 25 Interrelationships of Opioid, Dopaminergic, Cholinergic and GABAergic Pathways in the Central Nervous System.- 26 Selectivity of Ligands for Opioid Receptors.- 27 Development of Receptor-Selective Opioid Peptide Analogs as Pharmacologic Tools and as Potential Drugs.- 28 Ontogeny of Mammalian Opioid Systems.- Section D: Neurophysiology.- 29 Opioids and Sensory Processing in the Central Nervous System.- 30 Opioid Actions on Membrane Ion Channels.

Erscheint lt. Verlag	13.12.2011
Reihe/Serie	Handbook of Experimental Pharmacology
Co-Autor	H. Akil, S. Archer, A. Beaumont, M. Blum, D. Bronstein, S.R. Childers, A.D. Corbett, B.M. Cox, V. Dauge, R. Day, S. Dermer, J. Donnerer, A.W. Duggan, R. Elde, S.M. Fleetwood-Walker, L.D. Fricker, M.-C. Fournie-Zaluski, T.L. Gioannini, A. Goldstein, T. Hökfelt, V. Höllt, J.W. Holaday, H. Khachaturian, N. Kley, C.M. Knapp, H.W. Kosterlitz, N.M. Lee, F.M. Leslie, N. Levin, M.E. Lewis, J.P. Loeffler, H.H. Loh, D. Lorang, J.R. Lundblad, A. Mansour, A.H. Mulder, R.A. North, S.J. Paterson, D.E. Pellegrini-Giampietro, J.E. Pintar, F. Porreca, P.S. Portoghese, J.L. Roberts, B.R. Roques, J. Rossier, R.B. Rothman, M.K.H. Schäfer, P.W. Schiller, A.N.M. Schoffelmeer, R.E.M. Scott, E.J. Simon, A.P. Smith, J.A.M. Smith, S. Spector, A. Tempel, H. Teschemacher, K.A. Trujillo, E. Young, S.J. Watson, P.L. Wood, R.S. Zukin
Zusatzinfo	XXXVII, 815 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	1269 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
Themenwelt	Medizin / Pharmazie ► Pharmazie
Schlagworte	Base • Biochemie • biochemistry • endogenous ligand • Neurobiology • Opiat • Opioid • Opioider • Opioid Peptides • opioids • pharmacology • Pharmakologie
ISBN-10	3-642-77462-8 / 3642774628
ISBN-13	978-3-642-77462-1 / 9783642774621
Zustand	Neuware