Clinical Pharmacology of Antianginal Drugs

Buch | Softcover

XVI, 552 Seiten

2011 | 1. Softcover reprint of the original 1st ed. 1985
Springer Berlin (Verlag)
978-3-642-69526-1 (ISBN)

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When I was asked some years ago by the editors of the Handbook of Experimental Pharmacology to edit a new volume on Antianginal Drugs, I agreed on the condition that, in accordance with my scientific background, primary emphasis be given to clinical pharmacology and therapeutics. It soon turned out that, due to rapid developments in this field, nothing of the previous volume on Antianginal Drugs by Charlier (Vol. 31, 1971) could be retained apart from its basic idea of devoting considerable space to methodology. Since editors must operate within certain limits, I had to abstain from dealing with acute myocardial infarction in detail despite the well-known overlap between unstable angina, the preinfarction syndrome, and acute myocardial infarction. It was only possible for acute myocardial infarction and the concept of reduction of infarct size to be briefly discussed within the chapter on pathophysiology of acute coronary insufficiency. The chapter on invasive methods provided an opportunity to touch on new approaches to early intervention in acute myocardial infarction. Here, intracoronary streptokinase therapy and PTCA are considered, again with attention to the overlap between mechanical and pharmacological interventions.

General Principles.- 1 Epidemiology of Ischemic Heart Disease With 5 Figures.- 2 Pathophysiology of Coronary Circulation and of Acute Coronary Insufficiency With 11 Figures.- 3 Pharmacodynamic Principles of Action of Antianginal Drugs.- Test Methods.- 4 Experimental Testing of Antianginal Drugs in Animals.- 5 Noninvasive Methods: Systolic Time Intervals and Echocardiography With 2 Figures.- 6 Peripheral Circulation With 6 Figures.- 7 Exercise Testing With 3 Figures.- 8 Radionuclide Methods With 17 Figures.- 9 Assessment of Coronary Artery Disease and Myocardial Ischemia by Invasive Methods With 18 Figures.- Types of Antianginal Drugs.- 10 Organic Nitrates With 3 Figures.- 11 Molsidomine With 4 Figures.- 12 ?-Adrenoceptor Blocking Agents..- 13 Calcium Antagonists With 12 Figures.

Erscheint lt. Verlag	7.12.2011
Reihe/Serie	Handbook of Experimental Pharmacology
Co-Autor	U. Abshagen, W.E. Adam, W. Bleifeld, D.G. Gibson, S. Heyden, H.M. Hoffmeister, P.G. Hugenholtz, O. Kraupp, C. Nienaber, P.J. Oldershaw, B.N.C. Prichard, G. Raberger, D. Redwood, I.C. Roddie, J. Schaper, W. Schaper, J. Scholtholt, M. Stauch, W.F.M. Wallace
Zusatzinfo	XVI, 552 p.
Verlagsort	Berlin
Sprache	englisch
Maße	170 x 244 mm
Gewicht	979 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Kardiologie / Angiologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie ► PTA / PKA
Schlagworte	Drugs • pathophysiology • pharmacology • Physiology • PTCA • Research
ISBN-10	3-642-69526-4 / 3642695264
ISBN-13	978-3-642-69526-1 / 9783642695261
Zustand	Neuware