Antituberculosis Drugs

Buch | Softcover

XXIV, 566 Seiten

2011 | 1. Softcover reprint of the original 1st ed. 1988
Springer Berlin (Verlag)
978-3-642-72875-4 (ISBN)

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This volume deals specifically with those antituberculosis drugs which passed the preclinical phase and have been or are used in the treatment of tuberculosis and other mycobacterial diseases (except leprosy) in at least some parts of the world. Despite this restriction, there are 14 such drugs, and as a result this volume has reached rather large proportions. To prevent it from becoming even larger and more unwidely, most derivatives of antituberculotics have been omitted, especially where it is claimed that they provide only better bioavailibility or tolerability. Only in the chapter on the chemotherapy of diseases due to so-called atypical mycobacteria is the clinical use of the drugs described to a certain extent. In addition to antituberculotics, also discussed are antimicrobials which have been found to be effective against these mycobacteria. The sequence in which the drugs are described is historical, reflecting not the time of discovery but rather the first clinical application. This order was selected for reasons which are now no longer relevant. In this volume less emphasis is placed on detection, biological or synthetic production of antituberculotics, and structure-activity relationships. In contrast, emphasis is put on the degree, type, and mechanism of antimyco bacterial activity, pharmacokinetics, and biotransformation in animals and man, on experimental pharmacodynamics, and on the toxicity of antituberculotics used therapeutically.

1 Historical Introduction and Chemical Characteristics of Antituberculosis Drugs.- A. p-Aminosalicylic Acid (PAS).- B. Streptomycin (SM) - Dihydrostreptomycin (DHSM).- C. Thiosemicarbazone (TSC) [Thioacetazone, Thiacetazone, p-Aminobenzaldehyde].- D. Pyrazinamide (PZA) - Morphazinamide (MZA).- E. Isoniazid (INH).- F. Tetracyclines.- G. Viomycin (VM).- H. Cycloserine (CS) - Terizidone (TZ).- I. Thioamides: Ethionamide (ETH) - Protionamide (PTH).- J. Kanamycin (KM).- K. Thiocarlide (DATC).- L. Capreomycin (CM).- M. Ethambutol (EMB).- N. Rifampicin (RMP).- References will be found on each end of Paragraphs.- 2 Experimental Evaluation of Efficacy.- A. Introduction.- B. Methods, Their Limitations, Advantages, and Disadvantages.- References.- C. Drugs and Treatment Regimens.- 3 Experimental Evaluation of Chemoprophylaxis and Preventive Treatment in Animals.- A. Definitions.- B. Objectives of Laboratory Experiments.- C. Results of Animal Experiments.- D. Discussion of Experimental Data.- E. Preventive Treatment in Animals.- F. Immunological Questions of Chemoprophylaxis and Vaccine Prophylaxis.- References.- 4 Experimental and Clinical Activity of Antituberculosis Drugs and Other Antimicrobial Agents Against Mycobacteria Other than Tubercle Bacilli, Except M. Leprae.- A. Introduction.- B. Possible Reasons for the Lower Sensitivity of MOTT to many Antituberculotics Compared to M. tuberculosis.- C. Efficacy of Antituberculosis Drugs and Other Antimicrobial Agents Against the Various MOTT Species.- References.- 5 Experimental Pharmacology and Toxicology of Antituberculosis Drugs.- A. Introduction.- B. The Drugs.- 6 Mode of Action, Biotransformation and Pharmacokinetics of Antituberculosis Drugs in Animals and Man.- A. General Part.- B. Special Part - TheAntituberculosis Drugs.

Erscheint lt. Verlag	10.12.2011
Reihe/Serie	Handbook of Experimental Pharmacology
Co-Autor	K. Bartmann, H. Iwainsky, H.H. Kleeberg, P. Mison, H.A. Offe, H. Otten, D. Tettenborn, L. Trnka
Zusatzinfo	XXIV, 566 p.
Verlagsort	Berlin
Sprache	englisch
Maße	170 x 244 mm
Gewicht	1013 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Pneumologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
Schlagworte	Breathing • Chemotherapy • Kinetics • Pharmacokinetics • pharmacology • Research • Toxicology • Tuberculosis • Vaccine
ISBN-10	3-642-72875-8 / 3642728758
ISBN-13	978-3-642-72875-4 / 9783642728754
Zustand	Neuware