Leukocyte Typing II

Volume 2 Human B Lymphocytes

Ellis L. Reinherz, Barton F. Haynes, Lee M. Nadler, Irwin D. Bernstein (Herausgeber)

Buch | Softcover

562 Seiten

2011 | Softcover reprint of the original 1st ed. 1986
Springer-Verlag New York Inc.
978-1-4612-9328-6 (ISBN)

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The Second International Workshop on Human Leukocyte Differentia- tion Antigens was held in Boston, September 17-20, 1984. More than 350 people interested in leukocyte differentiation agreed to exchange reagents and participate in this joint venture. All in all, in excess of 400 antibodies directed against surface structures on T lymphocytes, B lymphocytes, and myeloid-hematopoietic stern cells were characterized. Because of the enormous quantity of serologic, biochemical, and functional data, Leuko- cyte Typing II has been divided into three volumes. These books represent the written results of workshop participants. They should be helpful to both researchers and clinicians involved in scientific endeavors dealing with these broad fields of immunobiology. To those who delve into the various sections of the volumes, it will become evident that the work speaks for itself. I am deeply indebted to the section editors, Barton F. Haynes, Volume 1, Human T Lymphocytes, Lee M. Nadler, Volume 2, Human B Lympho- cytes, and Irwin D.
Bernstein, Volume 3, Human Myeloid and Hemato- poietic Cells for their major contributions in planning, executing, and summarizing the workshop, as well as council members John Hansen, Alain Bernard, Laurence Boumsell, Walter Knapp, Andrew McMichael, Cesar Milstein, and Stuart F. Schlossman. I would also like to thank the National Institutes of Health, World Health Organization, and Interna- tional Union of Immunological Societies for making this meeting possible.

I. Introduction.- 1. B Cell/Leukemia Panel Workshop: Summary and Comments.- II. Serologic Specificity of B Cell/Leukemia Monoclonal Antibodies.- 2. Analysis of the B Cell/Leukemia Workshop Monoclonal Antibodies Using an Immunoenzymatic Staining Assay and a Radioimmunoassay on Cells.- 3. Analysis of Ten B Lymphocyte-Specific Workshop Monoclonal Antibodies.- 4. Screening of Workshop “B” Series Antibodies by Radioimmunobinding to Human Leukocyte Cell Lines and to Cells from Human Lymphoid Tumors.- 5. Expression of Lymphocyte Differentiation Antigens in Immunodeficiency Diseases.- 6. Use of Two Monoclonal Anti-Human B Cell Antibodies in the Study of Early B Cell Differentiation.- 7. Characterization of a Human B Lymphocyte-Specific Antigen Defined by Monoclonal Antibodies HD6 and HD39.- 8. Six Distinct Antigen Systems of Human B Cells as Defined by Monoclonal Antibodies.- 9. B-C1, B-C2, B-C3: Monoclonal Antibodies against B Cell Differentiation Antigens.- 10. Human B Cells: Is FMC7 a Marker for Relatively Mature B Cells or Does It Define a Population Equivalent to the LyB5-Negative Mouse B Cells?.- 11. Spontaneous Mouse Erythrocyte Rosette Formation (M-RFC) with Human B Lymphocytes: Diagnostic Value in B-Lymphoproliferative Diseases and Lack of Relationship to B Cell Protocol Monoclonal Antibodies.- III. Biochemical Analysis of Antigens Defined by the Workshop B Cell/Leukemia Panel.- 12. Human B Cell Surface Molecules Defined by an International Workshop Panel of Monoclonal Antibodies.- 13. Structural Analysis of Cell Surface Molecules Recognized by Leukemic Cell/B Cell Panel Antibodies.- 14. Biochemical Analysis of Antigens Recognized by Workshop B Series Antibodies, Using “Western Blotting”.- 15. Human B Cell Antigens Detected by the Workshop Antibodies: AComparison of Serological and Immunochemical Patterns.- 16. Further Evidence that the Human Differentiation Antigen p24 Possesses Activity Associated with Protein Kinase.- 17. Clustering of Anti-Leukemia and Anti-B Cell Monoclonal Antibodies.- 18. A Structurally Novel Human B Cell Surface Molecule.- 19. Human Neutrophils Synthesize Different Forms of the Common Acute Lymphoblastic Leukemia Antigen.- IV. Immunohistochemical Analysis of B Cell/Leukemia Panel Monoclonal Antibodies.- 20. Immunohistochemical Analysis of Monoclonal Anti-B Cell Antibodies.- 21. Analysis of B and L Workshop Antibodies on Sections of Normal and Neoplastic Lymphoid Tissue and Cell Lines.- 22. Immunohistological Analysis of Tissue Specificity of the Fifty-two Workshop Anti-B Lymphocyte Monoclonal Antibodies.- 23. Reactivity of Monoclonal Antibodies of the B and L Series with Follicular Dendritic Cells in Tissue Sections and with Lymphoblastoid Cell Lines.- 24. The Staining of a Panel of Routine Diagnostic Tissue Biopsies with the Workshop “L” Series Antibodies.- 25. Immunohistochemical Reactivity of Anti-B Cell Monoclonal Antibodies in Thymus, Lymph Node, and Normal Skin.- 26. Report to Second International Workshop on Human Leukocyte Differentiation Markers: Boston, 1984. Tissue Localization of B Cell and Leukemic Reagents (Special Studies).- V. Expression of B Cell/Leukemia Panel on Leukemias and Lymphomas.- 27. Quantitative Phenotypes of B Chronic Lymphocytic Leukemia B Cells Established with Monoclonal Antibodies from the B Cell Protocol.- 28. Analysis of Workshop “L” Series Antibodies: Radioimmunobinding and Biochemical Studies.- 29. Subclassification of Leukemia Using Monoclonal Antibodies.- 30. Immunological Classification of “Unclassifiable” Acute Leukemia.- 31. AgePredilection of Distinct Phenotypically Defined Subgroups of Non-T Cell ALL: Studies Using B Cell-Restricted or -Associated Monoclonal Antibodies in 359 Patients.- 32. Heterogeneity of B-CLL Cells Defined by Monoclonal Antibodies.- 33. HD37 Monoclonal Antibody: A Useful Reagent for Further Characterization of “Non-T, Non-B” Lymphoid Malignancies.- 34. Characterization of Burkitt’s Lymphoma Cell Lines with Monoclonal Antibodies Using an ELISA Technique.- VI. Functional Significance of Human B Cell/Leukemia Antigens.- 35. Human B Cell Populations Defined by the B1 and B2 Antigens.- 36. Phenotypic Changes Occurring during in vitro Activation of Human Splenic B Lymphocytes.- 37. Antigenic Changes of the B Cell Panel of the Second International Workshop on Human Leukocyte Differentiation Antigens with in vitro Activation.- 38. Activation of Human B Cells with Monoclonal Antibody to the Bp32 Cell Surface Polypeptide.- 39. B Lymphocyte Surface Antigens Involved in the Regulation of Immunoglobulin Secretion.- 40. Inhibition of Immunoglobulin Secretion, But Not Immunoglobulin Synthesis, by a Monoclonal Antibody.- 41. Monoclonal Antibody AB1 Identifies a Human B Cell Activation Antigen and Inhibits Growth Factor-Dependent Human B Cell Proliferation.- 42. Detection and Functional Studies of IL-2 Receptors on Activated Human B Cells.- 43. The C3d Receptor Identified by the HB-5 Monoclonal Antibody: Expression and Role as a Receptor for Epstein-Barr Virus.- 44. The B Cell-Restricted Glycoprotein (B2) Is the Receptor for Epstein-Barr Virus.- 45. Monoclonal Antibody-Defined Cell Surface Molecules Regulate Lymphocyte Activation.- 46. TPA-Induced Modulation of B Cell Differentiation Antigens Defined by Monoclonal Antibodies (HD6, HD28, HD37, HD39).- 47. Functional Studies of p24:Platelet Aggregation Inhibition by Fab Monomers of BA-2.

Zusatzinfo	XX, 562 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Themenwelt	Naturwissenschaften ► Biologie
Schlagworte	Lymphocytes
ISBN-10	1-4612-9328-6 / 1461293286
ISBN-13	978-1-4612-9328-6 / 9781461293286
Zustand	Neuware