Analgesic and NSAID-induced Kidney Disease
Oxford University Press (Verlag)
978-0-19-261956-3 (ISBN)
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Analgesic nephropathy, first recognized in 1950, was for two decades the most common cause of both acute and chronic renal failure in some parts of the world. This comprehensive text follows the story of the disease from its early description to its ultimatly sucessful prevention. The aetiology, pathology, diagnosis, and treatment are described by those who have played leading roles in elucidating the nature of the disease, and in persuading society to take effective measures to prevent its occurence. The second section describes those renal disorders resulting from the use of newer non-steroidal anti-inflammatory drugs and paracetamol - disorders which are rising in frequency and may prove more difficult to prevent. Finally, the book considers the urothelia cancers caused by phanacetin-containing headache powders, a late outcome of analgesic abuse. With contributions from a distinguished international group of authors, this is a unique book on a challenging problem. Throughout the text, theory and practice are integrated, and attention is drawn to the valuable lessons gained from the study of the analgesic nephropathies.
Historical introduction; The biochemistry and pharmacology of antipyretic-analgesics; Experimental evidence for nephrotoxicity of analgesics; The implications of analgesics in human kidney disease; The abuse of non-narcotic analgesics; The analgesic syndrome; The pathology of analgesic nephropathy; The diagnosis of analgesic nephropathy by organ imaging; Functional defects in analgesic nephropathy; Clinical presentations of analgesic nephropathy; Treatment of renal failure due to analgesics; Biochemistry and pharmacology of non-steroidal anti-inflammatory drugs and renal prostaglandins; Effects of non-steroidal anti-inflammatory drugs on renal function; Diseases of the kidney caused by non-steroidal anti-inflammatory drugs; Paracetamol-induced renal tubular cell necrosis; Experimental evidence and the biochemical basis for the role of analgesics in cancer; Analgesics as human carcinogens - clinical and epidemiological evidence; Carcinoma of the renal pelvis; Prevention of analgesic-induced kidney disease; References.
| Erscheint lt. Verlag | 25.2.1993 |
|---|---|
| Reihe/Serie | Oxford Clinical Nephrology Series ; v.2 |
| Zusatzinfo | black and white photographs, line drawings and tables |
| Verlagsort | Oxford |
| Sprache | englisch |
| Maße | 156 x 234 mm |
| Gewicht | 690 g |
| Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Nephrologie |
| Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie | |
| ISBN-10 | 0-19-261956-X / 019261956X |
| ISBN-13 | 978-0-19-261956-3 / 9780192619563 |
| Zustand | Neuware |
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