Immunosuppressant Analogs in Neuroprotection

Cesario V. Borlongan, Ole Isacson, Paul R. Sanberg (Herausgeber)

Buch | Softcover

378 Seiten

2012 | Softcover reprint of the original 1st ed. 2003
Humana Press Inc. (Verlag)
978-1-4684-9742-7 (ISBN)

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An authoritative survey of the most recent scientific evidence showing how cyclosporin, FK-506, and their analogs-the neuroimmunophilins-evolved from being purely immunosuppressant "drugs" to neuroprotective "agents". The book focuses on recent preclinical evidence that demonstrates the neurotrophic/neuroprotective effects of immunosuppressants when administered alone or when combined with neural transplantation therapy in animal models of neurological disorders. It also discusses their efficacy and mechanisms of action in vitro and in vivo models of CNS disease, and provides laboratory studies with compelling clinical indications for Alzheimer's disease, Huntington's disease, stroke, traumatic brain injury, spinal cord injury, ALS, sciatic nerve injury, and drug addiction.

I: Immunosuppressants, Neurologic Disorders, and Neuroprotection.- 1 • Introduction: Immunosuppressants as Neuroprotective Agents.- II: Immunosuppressants and Parkinson’s Disease.- 2 • Cyclosporin-Mediated Amelioration of Degeneration of Dopaminergic Neurons in Experimental Models of Parkinsonism.- 3 • Immunophilin Ligands and Dopamine Neurons: Specific Effects in Culture and In Vivo.- 4 • Effects of Neuroimmunophilin Ligands on Parkinson’s Disease and Cognition.- 5 • Improved Survival of Grafted Dopamine Neurons by Calcineurin Inhibitors.- 6 • Possible Mechanisms Underlying the Protective Action of Immunosuppressants Against Parkinson’s Disease: The Mitochondrial Permeability Transition Pore Hypothesis.- III: Immunosuppressants and other Age-Related Disorders.- 7 • Immunosuppressants and Alzheimer’s Disease.- 8 • Cyclosporin A Protects Striatal Neurons from Mitochondrial Dysfunction: Implications for Huntington’s Disease.- IV: Immunosuppressants, Stroke, and Traumatic Brain Injury.- 9 • Cyclosporin A Protects Mitochondria in an In Vitro Model of Hypoxia/Reperfusion Injury.- 10 • Protective Effect of Cyclosporin A on Glial Activation and White Matter Alterations Induced by Chronic Cerebral Hypoperfusion.- 11 • Blockade of Late-Onset Reduction of Muscarinic Acetylcholine Receptors by Immunosuppressants in Forebrain Ischemia.- 12 • The Role of Immunophilins in Focal Cerebral Ischemia: Evidence of Neuroprotection by FK506.- 13 • Immunosuppressants in Traumatic Brain Injury.- V: Immunosuppressants and Spinal Cord Injury.- 14 • Inhibition of Lipid Peroxidation by Cyclosporin After Spinal Cord Injury in Rats.- 15 • Axonal Regeneration in Cyclosporin A-Treated Rats Submitted to Transverse Section of the Spinal Cord.- VI:Immunosuppressants and Sciatic Nerve Injury.- 16 • Neuroimmunophilin Ligands Accelerate and Promote Nerve Regeneration in the Rat Peripheral Nerve and Spinal Cord: Role of the Steroid Receptor—FKBP52 Complex.- 17 • Neuroimmunophilin Ligands Stimulate Recovery of Injured Sciatic Nerves.- VII: Immunosuppressants and other Disorders of the Central Nervous System.- 18 • Cyclosporin A Prolongs Survival of SOD1 Mutant Mice and Implicates Mitochondrial Permeability Transition in Amyotrophic Lateral Sclerosis.- 19 • Psychological Effects of Cyclosporin A.

Forerword by Solomon H. Snyder

Erscheint lt. Verlag	3.12.2012
Zusatzinfo	XXVII, 378 p.
Verlagsort	Totowa, NJ
Sprache	englisch
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
ISBN-10	1-4684-9742-1 / 1468497421
ISBN-13	978-1-4684-9742-7 / 9781468497427
Zustand	Neuware