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Indacaterol

The First Once-daily Long-acting Beta2 Agonist for COPD

Alexandre Trifilieff (Herausgeber)

Buch | Hardcover

VII, 146 Seiten

2013 | 2014
Springer Basel (Verlag)
978-3-0348-0708-1 (ISBN)

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Here is a comprehensive overview of the development of Onbrez Breezhaler, a newly approved once-daily inhaled beta2 agonist for treating COPD. Covers design and pre-clinical pharmacology of the molecule, early clinical development, efficacy studies and more.

Chronic obstructive pulmonary disease (COPD) is a multi-component condition that results in increasingly limited airflow, usually associated with an abnormal inflammatory response of the lung. It constitutes a major public health burden worldwide, while only very few effective therapies are available.

This book provides a comprehensive overview of the development of Onbrez Breezhaler, a newly approved once-daily inhaled beta2 agonist for the treatment of COPD. It reviews the current pharmacotherapy for COPD and discusses topics such as the chemical design and the pre-clinical pharmacology of the molecule, the early clinical development, the INHANCE study (which provides a successful example of the use of an adaptive design in the confirmatory setting) and the Phase III clinical efficacy study, as well as the history and performance of the Breezhaler device. Finally, a list of emerging targets is included that could well offer future treatment options for COPD.

Current Pharmacotherapy for COPD.- The preclinical pharmacology of indacaterol.- The design of the indacaterol molecule.- The early clinical development of Indacaterol.- INHANCE: An adaptive confirmatory study with dose selection at interim.- Phase III clinical efficacy studies - lung function.- Phase III Clinical Efficacy of Indacaterol.- Patient-centered Outcomes.- The history and performance of the Breezhaler device.- What does the future hold for the therapy of COPD?

Erscheint lt. Verlag	27.11.2013
Reihe/Serie	Milestones in Drug Therapy
Zusatzinfo	VII, 146 p. 41 illus., 21 illus. in color.
Verlagsort	Basel
Sprache	englisch
Maße	155 x 235 mm
Gewicht	403 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Pneumologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
Schlagworte	Asthma • Beta-2-Agonists • Bronchitis • Bronchodilatator • lung function
ISBN-10	3-0348-0708-2 / 3034807082
ISBN-13	978-3-0348-0708-1 / 9783034807081
Zustand	Neuware