Basic Biology & Current Understanding of Skeletal Muscle

Buch | Hardcover

393 Seiten

2013
Nova Science Publishers Inc (Verlag)
978-1-62808-367-5 (ISBN)

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Skeletal muscle is a highly plastic tissue that constitutes approximately thirty percent of total body mass and adapts rapidly to changing functional demands. Skeletal muscle is not only the generator of force production, but also plays a crucial role in whole body metabolism and energy consumption. In this book, leading experts in the area of exercise biochemistry and molecular biology in skeletal muscle provide an up-to-date view of the molecular basis of various adaptations of skeletal muscle, with emphasis on new biological concepts (muscle stem cells, muscle steroidogenesis, etc). This book deals with the recent intriguing role of heat shock protein (HSP), AMPK and reactive oxygen species (ROS) for muscle morphology, function and metabolism. Discussed also is the molecular mechanism for protein metabolism and therapeutic application for sarcopenia. The deeper understanding of the signal transduction and modification in skeletal muscle will develop new therapeutic strategies for preventing physical disability and increased risk of morbidity/mortality due to the loss of muscle mass.

Stem Cell Hierarchies in Muscle Satellite Cells; Cellular Mechanisms Regulating Protein Metabolism in Skeletal Muscle Cells: Age-Associated Alteration of Intracellular Signaling Governing Protein Synthesis & Degradation; Biological Actions of Insulin-Like Growth Factor-I (IGF-I) Isoforms & IGF Binding Proteins in Skeletal Muscle; An Overview of the Therapeutic Strategies for Preventing Sarcopenia; Oxidative Stress-Induced Signal Transduction in Skeletal Muscle; The Functional Roles of Heat Shock Proteins in Skeletal Muscle; Mechanical Stress & Myofibrillar Structure; AMPK: Molecular Mechanisms of Metabolic Adaptations in Skeletal Muscle; A Role for Mitochondria as a Potential Regulator of Myogenesis; Skeletal Muscle Adaptation & Local Steroidogenesis; Index.

Verlagsort	New York
Sprache	englisch
Maße	180 x 260 mm
Gewicht	758 g
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Anatomie / Neuroanatomie
ISBN-10	1-62808-367-0 / 1628083670
ISBN-13	978-1-62808-367-5 / 9781628083675
Zustand	Neuware