Immunology of Renal Disease

Buch | Softcover

294 Seiten

2012 | Softcover reprint of the original 1st ed. 1991
Springer (Verlag)
978-94-010-5738-7 (ISBN)

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Although it has been appreciated for many years that immune processes underlie most types of glomerulonephritis, it is the recent explosion in knowl edge of cellular and molecular immunology that has prompted another book on the subject. The understanding of the mechanisms involved in renal injury requires the integration of information from in vitro cell-culture systems, experimental models of disease, and clinical studies. This volume draws on all of these sources in an attempt to explain current concepts of nephritis. Increased emphasis is placed on autoimmune processes, as opposed to the deposition of circulating immune complexes, although it will be apparent that these may overlap in the area of "in situ" immune complex formation. Of central importance in autoimmunity is the relationship between antigen pre senting cells (including B cells) expressing MHC class II molecules, autoan tigenic peptides, T helper lymphocytes, and various effector cells. The mechanisms by which the immune system may lead to tissue injury are also becoming better understood, and consideration is given to the role of inflam matory cells, the complement proteins, and soluble factors such as cytokines and eicosanoids.

1 Immunogenetics of nephritis.- 2 Introduction and regulation of autoimmune experimental glomerulonephritis.- 3 Molecular mechanisms of in situ immune complex formation in experimental membranous nephropathy.- 4 Immune complex handling in systemic lupus erythematosus.- 5 The membrane attack complex of complement in renal injury.- 6 Cell-mediated immunity in glomerulonephritis.- 7 Eicosanoids and cytokines in glomerular injury.- 8 Immunology of minimal-change nephropathy.- 9 IgA nephropathies and Henoch-Schonlein purpura.- 10 C3 nephritic factor and membranoproliferative glomerulonephritis.- 11 Anti-glomerular basement membrane disease.- 12 Autoimmunity in systemic vasculitis.- 13 Immunopathogenic mechanisms of interstitial nephritis.

Erscheint lt. Verlag	8.11.2012
Reihe/Serie	Immunology and Medicine ; 16
Zusatzinfo	X, 294 p.
Verlagsort	Dordrecht
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Nephrologie
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
ISBN-10	94-010-5738-9 / 9401057389
ISBN-13	978-94-010-5738-7 / 9789401057387
Zustand	Neuware