Hematopoietic Growth Factors in Oncology

Basic Science and Clinical Therapeutics

George Morstyn, MaryAnn Foote, Graham J. Lieschke (Herausgeber)

Buch | Softcover

477 Seiten

2012 | Softcover reprint of the original 1st ed. 2004
Humana Press Inc. (Verlag)
978-1-4684-9847-9 (ISBN)

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Leading oncologists, hematologists, and nephrologists comprehensively review the role of HGFs in clinical practice, explain the molecular basis of their effects, and consider potential future developments. The authors focus on the use of HGFs in oncology, describing their cutting-edge application to patients with lung cancer, Hodgkin's and nonhodgkin's lymphoma, breast cancer, chronic lymphocytic leukemia, AIDS-related malignancies, myelodysplastic syndromes, and aplastic anemias. Among the HGFs described are granulocyte colony-stimulating factor, erythropoietc factors, thrombopoietic factors, and stem cell factor and its receptor, C-kit. To complete their survey, the contributors also consider the safety and economic implications of HGFs and the future potential for HGF antagonists in oncology.

I. Basic Research.- 1 Introduction to Hematopoietic Growth Factors: A General Overview.- 2 Animal Models of Hematopoietic Growth Factor Perturbations in Physiology and Pathology.- 3 The Jak/Stat Pathway of Cytokine Signaling.- 4 Small-Molecule and Peptide Agonists: A Literature Review.- II. Hematopoietic Growth Factors.- 5 Granulocyte Colony-Stimulating Factor.- 6 Erythropoietic Factors: Clinical Pharmacology and Pharmacokinetics.- 7 Thrombopoietin Factors.- 8 Stem Cell Factor and Its Receptor, c-Kit.- 9 Hematopoietic Growth Factors: Preclinical Studies of Myeloid and Immune Reconstitution.- III. Use of Hematopoietic Growth Factors in Oncology.- 10 Commentary on the ASCO and ESMO Evidence-Based Clinical Practice Guidelines for the Use of Hematopoietic Colony-Stimulating Factors.- 11 Neutropenia and the Problem of Fever and Infection in Patients With Cancer.- 12 Thrombocytopenia and Platelet Transfusions in Patients With Cancer.- 13 Hematopoietic Growth Factors in Lung Cancer.- 14 Role of Hematopoietic Growth Factors As Adjuncts to the Treatment of Hodgkin’s and Non-Hodgkin’s Lymphomas.- 15 Use of Granulocyte Growth Factors in Breast Cancer.- 16 Role of Cytokines in the Management of Chronic Lymphocytic Leukemia.- 17 Hematopoietic Growth Factor Therapy for Myelodysplastic Syndromes and Aplastic Anemia.- 18 Use of Hematopoietic Growth Factors in AIDS-Related Malignancies.- IV. Safety and Economic Implications.- 19 The Safety of Hematopoietic Growth Factors.- 20 Long-Term Safety of Filgrastim in Chronic Neutropenias.- 21 Economics of Hematopoietic Growth Factors.- V. Future Directions.- 22 Potential for Hematopoietic Growth Factor Antagonists in Oncology.- Acronyms and Selected Abbreviations.

"Comprehensive and up-to-date...offers an integrated survey of the role of HGFs in treating and preventing anemia, neutropenia, and thrombotopenia in patients wit malignant diseases, along with fresh insights into drug development and how basic discoveries in this area can be optimally translated into clinical benefit." - Tumori

Erscheint lt. Verlag	22.7.2012
Reihe/Serie	Cancer Drug Discovery and Development
Zusatzinfo	X, 477 p.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Hämatologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
ISBN-10	1-4684-9847-9 / 1468498479
ISBN-13	978-1-4684-9847-9 / 9781468498479
Zustand	Neuware