Molecular Signaling of Mammalian Inner Ear Development

Buch | Hardcover

230 Seiten

2013
Nova Science Publishers Inc (Verlag)
978-1-62618-992-8 (ISBN)

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The inner ear originates from an ectodermal thickening, the otic placode, which lies adjacent to the developing hindbrain. Complex interactions between regulatory signalling molecules guide development of the simple otic placode into the elaborate, multifunctional organs of hearing and balance. This book delves into recent research in the field, focusing on successive stages of inner ear development and how they are influenced by the co-ordinate activity of signalling molecules. This book begins with an overview of the evolutionary adaptation of the organ of Corti (organ of hearing) and the molecular signals that characterise ancestral development of the inner ear. Following this, the topics addressed include the complex signalling interactions underlying induction of the otic placode, key molecular mediators influencing inner ear development and patterning, genetic signalling of the vestibular (balance) system and clinical correlations to human balance disorders, commitment to auditory hair cell fate, and reliance of the inner ear on retinoic acid, a biologically-active derivative of vitamin A, for appropriate development. This timely and comprehensive book provides an excellent resource for researchers, clinician-scientists and students alike.

Preface; Evolution of the Mammalian Auditory System: An Integrated Perspective of the Molecular Development; Induction & Morphogenesis of the Inner Ear; Function & Regulation of Fibroblast Growth Factors in the Developing Otic Epithelium; BMP Signaling during Inner Ear Development; Role of Hedgehog & Wnt Signaling in Mammalian Inner Ear Formation; Genetic Signal Pathways that Control the Development of the Vestibular System & Clinical Correlates in Patients with Balance Disorders; Determination of Hair Cell Fate in the Cochlea: Molecular Signaling Pathways; Retinoic Acid Signaling in the Developing Otocyst; Index.

Erscheint lt. Verlag	1.7.2013
Verlagsort	New York
Sprache	englisch
Maße	180 x 260 mm
Gewicht	516 g
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Anatomie / Neuroanatomie
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
ISBN-10	1-62618-992-7 / 1626189927
ISBN-13	978-1-62618-992-8 / 9781626189928
Zustand	Neuware