Taurine 4

Taurine and Excitable Tissues

Laura Della Corte, Ryan J. Huxtable, Giampietro Sgaragli, Keith F. Tipton (Herausgeber)

Buch | Hardcover

652 Seiten

2001
Kluwer Academic/Plenum Publishers (Verlag)
978-0-306-46447-8 (ISBN)

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Mitochondria from mammalian tissues possess an elaborate system for 2+ 2+ transporting Ca across their inner membrane which consists of Ca import, 2+ via the Ca uniporter, in response to the mitochondrial membrane 2+ + potential ?? and of Ca release by an antiport system in exchange for H + 9,23 or Na (see Fig. l) . Because the uniporter is dependent upon the external 2+ 2+ 2+ 2+ Ca concentration ([Ca ]), mitochondria accumulate Ca until the [Ca ] o o 2+ decreases to the level at which the uniporter activity balances the Ca efflux. 2+ The [Ca ] at which the uniporter and efflux activities are equal is defined o the “setpoint” andcorresponds to values between 0.3-3µM. 2+ Figure 1. The Ca transport system of the inner membrane of mammalian mitochondria. U, + 2+ + + uniporter. I, Na -independent efflux mechanism or Ca /2H exchanger. D, Na -dependent 2+ + efflux mechanism or Ca /2Na exchanger. PTP, permeability transition pore. FP, 11 flavoprotein. ?? membrane potential. ? pH gradient. Adapted from .

Keynote Presentation.- Appreciations.- Plenary Presentations.- Basic Aspects and Peripheral Actions of Taurine.- Metabolic and Nutritional Aspects.- Taurine in the CNS.- Taurine Analogues and Metals: Health Care Aspects.- Taurine and Vision.- Taurine and Cell Homeostatic Mechanisms.- Clinical Aspects.

Erscheint lt. Verlag	31.1.2001
Reihe/Serie	Advances in Experimental Medicine and Biology ; 483
Zusatzinfo	XXIV, 652 p.
Verlagsort	New York
Sprache	englisch
Maße	156 x 234 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	0-306-46447-0 / 0306464470
ISBN-13	978-0-306-46447-8 / 9780306464478
Zustand	Neuware