Detection Challenges in Clinical Diagnostics

Pankaj Vadgama, Serban Peteu (Herausgeber)

Buch | Hardcover

246 Seiten

2013
Royal Society of Chemistry (Verlag)
978-1-84973-612-1 (ISBN)

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There are many remaining challenges impeding future progress in field of Clinical Diagnostics. This book presents a technical assessment and vision of clinical leaders, scoping the clinical and other diagnostic needs and the bottle-necks in their cognate fields. Issues of real environmental biological measurements from the perspective of the end-user are presented and thus the book serves to inform the direction of the fundamental scientific efforts. Both editors are experienced practitioners within the biosensor technology and are involved first-hand with the healthcare and clinical applications of detection science.

Professor Pankaj Vadgama's particular interest is biosensors, where he has developed permselective, biocompatible, and biomimetic polymeric membranes capable of stable transduction in whole blood and tissue. Both in vivo and in vitro work has been undertaken, including the use of miniaturized devices for glucose and lactate monitoring, immunosensing, and interrogation of tissue-material interactions. Current research work includes interfacial problems relating to sensor/biomaterial contact with the biomatrix, and the generalizable insights that may emerge from this. Projects include: spider silk for tissue engineering, materials for implantable electronic devices, microfluidic based separation, cell-surface interactions, biomaterial degradation dynamics, conducting polymers as biomaterials, tissue bioreactor design, and cochlear implant electrodes. Dr. Serban Peteu's research interest is in biosensors, where he has advanced methods to detect metal ions or monitor nitro-oxidative stress in biological fluids. Both electrochemical and optochemical sensing have been investigated, furthermore the response being enhanced via hybrid organic-inorganic nano-architectures. Present work involves nanowire based bio-catalytic interfaces for electrochemical and field-effect sensors. Projects include: semiconductor based lancet type biosensors, electroactive polymers soft actuators, bioreactors designed and fabricated for vaccine research and for water remediation, other equipment and devices to improve the quality of life.

Introduction;

Sensitive detection as an interface process;

Improved ion-, gas- and bio-sensors;

Long term implantable sensors;

Ultrasensitive Protein microarrays;

Monitoring nitro-oxidative stress;

Nano-bio-interface diagnostics;

Discussion and conclusions

Reihe/Serie	Detection Science ; Volume 2
Verlagsort	Cambridge
Sprache	englisch
Maße	156 x 234 mm
Gewicht	547 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
	Studium ► 2. Studienabschnitt (Klinik) ► Anamnese / Körperliche Untersuchung
	Naturwissenschaften ► Chemie ► Analytische Chemie
ISBN-10	1-84973-612-X / 184973612X
ISBN-13	978-1-84973-612-1 / 9781849736121
Zustand	Neuware