Human Chromosomes

Orlando J. Miller, Eeva Therman (Autoren)

Buch | Hardcover

501 Seiten

2000 | 4th ed. 2001
Springer-Verlag New York Inc.
978-0-387-95031-0 (ISBN)

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This is the fourth edition of an acclaimed introductory textbook on the structure and function of human chromosomes. The explosion of information on human genetic diseases has meant that there is a greater need than ever for students, practising physicians, laboratory technicians, and researchers to have a concise, up-to-date summary of the normal and abnormal behavior of chromosomes. This book continues to fulfill that need, and is strengthened by the complete revision of material on the molecular genetics of chromosomes and chromosomal defects.

1 Origins and Directions of Human Cytogenetics.- 2 The Mitotic Cell Cycle.- 3 DNA Replication and Chromosome Reproduction.- 4 General Features of Mitotic Chromosomes.- 5 The Chemistry and Packaging of Chromosomes.- 6 Chromosome Bands.- 7 Molecular Correlates of Chromosome Bands.- 8 In Situ Hybridization.- 9 Main Features of Meiosis.- 10 Details of Meiosis.- 11 Meiotic Abnormalities: Abnormal Numbers of Chromosomes.- 12 Abnormal Phenotypes Due to Autosomal Aneuploidy or Polyploidy.- 13 Chromosome Structural Aberrations.- 14 The Causes of Structural Aberrations.- 15 Syndromes Due to Autosomal Deletions and Duplications.- 16 Clinical Importance of Translocations, Inversions, and Insertions.- 17 Sex Determination and the Y Chromosome.- 18 The X Chromosome, Dosage Compensation, and X Inactivation.- 19 Phenotypic Effects of Sex Chromosome Imbalance.- 20 Fragile Sites, Trinucleotide Repeat Expansion, and the Fragile X Syndrome.- 21 Euploid Chromosome Aberrations, Uniparental Disomy, and Genomic Imprinting.- 22 Chromosome Changes in Cell Differentiation.- 23 Somatic Cell Hybridization in Cytogenetic Analysis.- 24 Chromosome Instability Syndromes.- 25 DNA and Gene Amplification.- 26 Genome Destabilization and Multistep Progression to Cancer.- 27 Chromosomes and Cancer: Activation of Oncogenes.- 28 Chromosomes and Cancer: Inactivation of Tumor Suppressor Genes.- 29 Mapping Human Chromosomes.- 30 Genome Plasticity and Chromosome Evolution.- 31 The Future of Human Cytogenetics.

Zusatzinfo	XVI, 501 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
ISBN-10	0-387-95031-1 / 0387950311
ISBN-13	978-0-387-95031-0 / 9780387950310
Zustand	Neuware