Advances in Twin and Sib-pair Analysis
Greenwich Medical Media Ltd (Verlag)
978-1-84110-004-3 (ISBN)
- Titel ist leider vergriffen;
keine Neuauflage - Artikel merken
Twin and family data have traditionally been used to quantify the genetic and environmental contribution to disease. Through the application of new analytical approaches, these designs can also provide powerful models in which the search for specific genes underlying non-Mendelian diseases can be optimised. This book discusses the state-of-the-art in twin and sib-pairs analysis of complex diseases both from the perspective of epidemiology (study design, subject selection, sampling strategies) and biostatistics (path analysis, survival analysis, linkage analysis, association studies). Novel ways are discussed in which twins and sib-pairs can be used to meet the challenge of identifying the location and function of genes underlying complex traits. This book will appeal to a wide range of biomedical scientists interested in the genetic basis of disease, epidemiologists, molecular biologists, human geneticists and students.
1. Introduction / 2. Influence of design on the outcome of twin studies / 3. Sample selection and outcome definition in twin studies; experiences from the Finnish twin cohort study / 4. Practical approaches to account for bias and confounding in twin data / 5. The co-twin control study / 6. Generalisability and assumptions of twin studies / 7. Fetal programming or genes? / 8. twin and sib-pair studies in developing countries / 9. Comparison of analysis of variance and likelihood models of twin data analysis / 10. Path analysis of age-related disease traits / 11. Survival analysis methods in twin research / 12. Gene-environment interaction and twin studies /13. Why common environmental effects are so uncommon in the literature / 14. Using sib-pairs and parent-child trios in association studies / 15. The concept of genome-wide power and a consideration of its potential use in mapping polygenic traits:the example of sib-pairs / 16. The use of twins in quantitative trait locus mapping / 17. Multivariate QTL analysis using structural equation modeling: a look at power under simple conditions / 18.QTL mapping with sib-pairs: the flexibility of Mx / 19. Implications of pharmacogenetic polymorphisms for human health
| Erscheint lt. Verlag | 10.1.1999 |
|---|---|
| Zusatzinfo | 20 Line drawings, unspecified |
| Verlagsort | Cambridge |
| Sprache | englisch |
| Maße | 154 x 234 mm |
| Gewicht | 555 g |
| Themenwelt | Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik |
| Studium ► Querschnittsbereiche ► Epidemiologie / Med. Biometrie | |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| ISBN-10 | 1-84110-004-8 / 1841100048 |
| ISBN-13 | 978-1-84110-004-3 / 9781841100043 |
| Zustand | Neuware |
| Haben Sie eine Frage zum Produkt? |
aus dem Bereich
