Free Radicals in the Pathogenesis of Liver Injury

Proceedings

P.A. Poli, K.H. Cheeseman, M. U. Dianzani, Trevor F. Slater (Herausgeber)

Buch | Hardcover

330 Seiten

1989
Pergamon (Verlag)
978-0-08-037382-9 (ISBN)

Infos

Since the first Congress on Free Radicals in Liver Injury took place in 1985, much research and development has taken place in this area of liver pathophysiology which is now considered to be of prime interest and importance in hepatology. In these Proceedings of the second Congress, held in Turin in June 1988, the most recent advances in the study of free radical mechanisms, from the organic to the molecular level in both acute and chronic liver injuries are discussed, in both experimental animals and man. The first section covers the remarkable advances that have been made in the clarification of biochemical mechanisms connecting oxidative insult to hepatocyte death. Stimulating new data on the role of free radicals and lipid peroxidation in the development of hepatocellular carcinoma and in liver regeneration appear in the second section. The papers in the third section investigate the involvement of oxidative species in the pathology of chronic liver diseases, notably alcoholic liver injury.

Inhalt

Section Headings and Selected Papers: Section One: Oxidative Stress and Hepatocyte Damage. Lipid peroxidation and antioxidant systems in the liver injury induced by glutathione depleting agents, A F Casini et al. Effects of free radicals on hormonally- and non-hormonally-regulated calcium homeostasis in rat liver microsomes and hepatocytes, F B Pruijn & A Bast. S;icidal inactivation of haem by halothane, M Manno. Section Two: Free Radicals and Liver Cancer. Genotoxic effects of 4-hydroxyalkenals, P Eckle & H Esterba;er. Evaluation of methylglyoxal genotoxicity in the rat using the micronucleus assay in liver and bone-marrow cells, A Martelli et al. Possible role of free radicals in liver regeneration, L Lambotte et al. Section Three: Free Radicals in Chronic Liver Diseases. Free radical-related liver mitochondrial damage following experimental chronic iron overload, H Rouach et al. Role of free radicals in ethanol-induced acute hepatotoxicity, M Younes & O Strubel;. The role of lipid peroxidation and antioxidants in alcoholic liver disease in man, S Moscarella et al. Section Four: Antioxidant Defences in Liver Injury. Calcium and oxidative stress in the hepatocyte model for cell injury, D J Reed & C E Thoma;. Antioxidant effects of ascorbate and glutathione in microsomal lipid peroxidation are dependent on vitamin E, H Wefers & G Sies. A;tioxidant status in alcoholic liver disease, R J Ward et al. 800 lit. refs. approx., 2 halftones, 99 line drawings

Produkt-Details

• Zusatzinfo: 101ill.
• Verlagsort: Amsterdam
• Sprache: englisch
• Gewicht: 1000 g
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Gastroenterologie
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Hepatologie
• ISBN-10: 0-08-037382-8 / 0080373828
• ISBN-13: 978-0-08-037382-9 / 9780080373829
• Zustand: Neuware