Applications of Antisense Therapies to Restenosis

Buch | Softcover

184 Seiten

2012 | Softcover reprint of the original 1st ed. 1999
Springer-Verlag New York Inc.
978-1-4613-7361-2 (ISBN)

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Restenosis, the proliferation of smooth muscle cells (SMC) that line blood vessels, often follows angioplasty. Despite advances in cardiology, restenosis continues to affect up to 40% of the over 500,000 patients who undergo angioplasty each year. Applications of Antisense Therapies to Restenosis is the first volume to address the potential of using antisense therapies to inhibit the restenosis that occurs after percutaneous transluminal angioplasty and coronary stenting. The work critically examines the application of various antisense therapies for inhibiting restenosis.

1 Restenosis: The Clinical Problem.- 2 The Pathobiology of Restenosis. A Paradigm from Clinical and Experimental Studies.- 3 Coronary Repair and Restenosis Cellular Basis for Antisense Approaches.- 4 Vascular Smooth Muscle Cell Biology and Restenosis.- 5 Vascular Antisense Therapy Directed Against c-myc, c-myb, and PCNA.- 6 Phosphorothioate Oligodeoxynucleotides as Inhibitors of gene Expression: Antisenseand Non-Antisense Effects.- 7 Molecular Therapies for Vascular Disease: Altering the Balance Between Cell growth and Cell Death.- 8 Oligonucleotides Containing the G-Quartet Sequence Motif.- 9 Non-G-Quartet, Non-Sequence Specific Antirestenotic Effects of Phosphorothioate Oligodeoxynucleotides.- 10 Local Delivery of Antirestenotic Drugs.- 11 Critical Considerations and Future Directions.

Reihe/Serie	Perspectives in Antisense Science ; 3
Zusatzinfo	VIII, 184 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizinische Fachgebiete ► Chirurgie ► Herz- / Thorax- / Gefäßchirurgie
	Medizinische Fachgebiete ► Innere Medizin ► Kardiologie / Angiologie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
ISBN-10	1-4613-7361-1 / 1461373611
ISBN-13	978-1-4613-7361-2 / 9781461373612
Zustand	Neuware