Protein Degradation in Health and Disease

Buch | Softcover

X, 130 Seiten

2012 | 1. Softcover reprint of the original 1st ed. 2002
Springer Berlin (Verlag)
978-3-642-62714-9 (ISBN)

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Protein degradation has been identified as a major mechanism for the regulation of cellular functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated.

Roles of SCF and VHL Ubiquitin Ligases in Regulation of Cell Growth.- Aging of Proteins and the Proteasome.- Protein Degradation in the Aging Organism.- Protein Degradation in Alzheimer's Disease and Aging of the Brain.- Protein Degradation in Human Disease.- The 26S Proteasome.- Proteasome Inhibitors.

Erscheint lt. Verlag	5.11.2012
Reihe/Serie	Progress in Molecular and Subcellular Biology
Zusatzinfo	X, 130 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	229 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	aging • Alterungsprozess • Alzheimer • Alzheimer's disease • Cancer • Cell • central nervous system • Development • Diseases • Krebs • Metabolism • Pathology • Proliferation • Proteasome • Protein • Proteinabbau • Protein degradation • proteins • Regulation • Ubiquitination
ISBN-10	3-642-62714-5 / 3642627145
ISBN-13	978-3-642-62714-9 / 9783642627149
Zustand	Neuware