Biochemical Pharmacology as an Approach to Gastrointestinal Disorders

Basic Science to Clinical Perspectives (1996)

Timothy S. Gaginella, K. D. Rainsford, Gyula Mózsik (Herausgeber)

Buch | Softcover

396 Seiten

2012 | Softcover reprint of the original 1st ed. 1997
Springer (Verlag)
978-94-010-6267-1 (ISBN)

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3 The help of Mr Phil Johnstone and editorial staff at Kluwer Academic Publishers in producing this book and the publication in the Journal is most gratefully acknowl- edged. INFLAMMOPHARMACOLOGY Basic and clinical studies on Inflammation and its phannacologlcal control Aim. and Scope The joumal Innammopharmacology publishes papers on all aspects of inflammation and its phannacological control, emphasizing comparisons of (a) dillerent inflammatory states, and (b) the actions, therapeutic eflicacy and safety of dr/lgs employed in the treatment of inflammatory conditions. The comparative aspects of the types of inflammatory conditions include gastrointestinal disease (e. g. ulcerative colitis, Cmhn's dsease) i , parasitic diseases, toxicological manifestations of the effects of dr/lgs and envimnmental agents, and arthritic conditions. Inflammophannacology covers all the major aspects of the experimentally-induced clinical pathology, Its bkx:hemistry and cell biology, as well as the clinical and experimental phannacology and toxk:ology of therapeutic agents.
The emphasis on comparative aspects of the actions of drugs Is intended to highlight their eflicacy and toxicity pmfiles as well as the variability In their clinical response and safety.

Introduction: Advances in the biochemical pharmacology of gastrointestinal (GI) functions as an approach to understanding GI disorders.- I. Gastrointestinal Secretory and Excretory Functions.- Possible compensation in epidermal growth factor production by saliva in rat.- Regulatory mechanism of acid secretion in rat stomach after damage — role of nitric oxide, histamine and sensory neurons.- Secretory pathways in histamine-containing enterochromaffin-like cells of rat stomach.- Nitric oxide as a modulator of fluid absorption in rat jejunum in vivo.- Mechanism of cholera.- Critical evaluation of acinar, ductal, vascular and intestinal intraluminal factors influencing pancreatic cytoprotection.- Peptide receptor antagonists and monoclonal antibodies raised against peptides: tools to study physiological regulation of pancreatic function.- Mechanisms and regulation of Cl- secretion in the large intestine: studies with the rat distal colon.- II. Gastrointestinal Motility.- Prostaglandin E2: actions on the circular and longitudinal contractions of the canine colon.- Gastric motor effects of endothelins in the lower brainstem of the rat.- Effects of erythromycin on the propulsive motility of upper gastrointestinal tract in rats.- Bicuculline blocks the inhibitory effects of substance P but not vasoactive intestinal polypeptide on gastric motor function in the nucleus raphe obscurus of the rat.- Pathological basis and clinical aspects of oesophageal motor disorders.- III–IV. Biochemical—Pharmacological Mechanisms in Neural and Hormonal Normal and Pathological Reactions Involved in GI Functions.- Distribution of muscarinic receptor mRNAs in the stomach of normal or immobilized rats.- Changes of sensory neuropeptides in experimental gastrointestinal diseases.- V. GI MucosalInjury and Protection.- Biochemical energetical backgrounds and their regulation in the gastric corpus mucosa in patients with different gastric secretory responses.- Oxidative stress and its prevention in toxic liver lesions. An overview.- The effect of drugs on liver function and biliary secretion.- Alteration of microvascular regeneration and permeability during acetic acid-induced gastric ulcer healing: effect of basic fibroblast growth factor.- Modulation of gastric wound repair by hepatocyte growth factor and basic fibroblast growth factor.- The effect of resiniferatoxin on experimental gastric ulcer in rats.- AIDS treatment and the heat shock protein level in the gastrointestinal tract.- ELISA and Western blot studies with basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) in experimental duodenal ulceration and healing.- Biological oxidants as intestinal secretagogues.- A new uniform biochemical explanation for the development and location of ‘genuine’ gastric, duodenal and jejunal ulcers in patients.- VI. Molecular Mechanisms of Premalignant and Malignant Diseases in GI Tract.- Current problems and results of tumour immunology: diagnostic and therapeutic relevance of tumour-associated antigens.- VII. Use of Isolated Cells and Cell Cultures in Biochemical Pharmacological Studies to Approach GI Diseases.- Does omeprazole-induced hypergastrinaemia contribute to the enhanced healing of acetic acid-induced gastric ulcers in rats?.- Modification of pathobiological events by potential hepatopharmacological agents.- Organoprotection and cytoprotection of histamine differ in rats.- Comparative viability studies on isolated gastric mucosal mixed cells and hepatoma and myeloma cell lines with ethanol, indomethacin and their combination.

Zusatzinfo	X, 396 p.
Verlagsort	Dordrecht
Sprache	englisch
Maße	160 x 240 mm
Themenwelt	Medizinische Fachgebiete ► Chirurgie ► Viszeralchirurgie
	Medizinische Fachgebiete ► Innere Medizin ► Gastroenterologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
ISBN-10	94-010-6267-6 / 9401062676
ISBN-13	978-94-010-6267-1 / 9789401062671
Zustand	Neuware