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The Molecular Basis of Blood Diseases - George Stamatoyannopoulos, Philip W. Majerus, Roger M. Perlmutter, Harold Varmus

The Molecular Basis of Blood Diseases

Buch | Hardcover
1064 Seiten
2000 | 3rd Revised edition
W B Saunders Co Ltd (Verlag)
978-0-7216-7671-5 (ISBN)
CHF 469,95 inkl. MwSt
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This third edition covers regulatory mechanisms and biological responses involving cytokines and chemokines and hematologic growth factors. The work discusses scientific bases of transfusion protocols and targets for monoclonal antibody therapy, and molecular mechanisms in lymphoma pathobiology.
The superb 3rd Edition covers all the groundbreaking developments that have taken place in this field since the publication of the well-received 2nd Edition. Comprehensively revised, it presents all the newest findings on the molecular bases of blood cell functions and disease mechanisms...and the impact of these discoveries on the state of medicine.

PART I: Hematopoiesis Stem Cell Biology Hemopoietic Growth Factors and Receptors Transcriptional Factors that Regulate Lineage Decisions Growth Factor Signaling PART II: Red Cells Hemoglobin Switching The Thalassemias Human Hemoglobins: Sickle Cell Hemoglobin and Other Mutants The Erythrocyte Membrane and Cytoskeleton: Structure, Function, and Disorders Red Blood Cell Antigenes Molecular Basis of Iron Metabolism PART III: Lymphopoiesis Gene rearrangements in Lymhoic Cells Lymphoiesis Antigen Processing and T-Cell Effector Mechanisms PART IV: Myelopoiesis/White Blood Cells Integrins, Selectins, and LAD Chemokines Genetic Disorders of Phagocyte Function Paroxymal Nocturnal Hemoglobins PART V: Hemostasis Vitamin K-Dependent Proteins The Protein C Anticoagulant System Regulation of Blood Coagulation by Protease Inhibitors Hemophilia A, Hemophilia B, and von Willenbrand Disease The Molecular Basis of Fibrin Fibrinilysis and the Control of Hemostasis Platelets PART VI: Molecular Oncology Molecular Aspects of Oncogenesis Mechanisms of Leukemogenesis PART VII: Viruses The Molecular and Biological Properties of the Human Immunodeficiency Virus Viral Pathogenesis of Hematological Disorders B19 Parvoviruses HTLVs Herpesviruses Gene Therapy of Hemopoietic Diseases

Erscheint lt. Verlag 28.9.2000
Zusatzinfo 402 ills(24 in full color)
Verlagsort London
Sprache englisch
Maße 216 x 279 mm
Gewicht 2755 g
Themenwelt Medizinische Fachgebiete Innere Medizin Hämatologie
Naturwissenschaften Biologie Genetik / Molekularbiologie
ISBN-10 0-7216-7671-5 / 0721676715
ISBN-13 978-0-7216-7671-5 / 9780721676715
Zustand Neuware
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