The Thalassaemia Syndromes (eBook)

David J. Weatherall, J. B. Clegg (Autoren)

eBook Download: PDF

2008 | 4. Auflage
864 Seiten
John Wiley & Sons (Verlag)
978-0-470-69594-4 (ISBN)

Infos

In the new edition of this successful and authoritative book, the thalassaemias are reviewed in detail with respect to their clinical features, cellular pathology, molecular genetics, prevention and treatment. It is aimed at specialists in haematology in the laboratory or clinical setting, particularly in areas where thalassaemia is common either in the native population or in immigrant communities.

The fourth edition has been both updated and re-organized. Three new chapters have been added on the link between alpha-thalassaemia and mental retardation, on avoidance and population control and on global epidemiology. Considerable emphasis is placed on molecular pathology reflecting the huge burst of information to have come out of this field in the last few years.

Autor

Sir David John Weatherall, GBE, FRS is a British physician and researcher in molecular genetics, haematology, pathology and clinical medicine. J. B. Clegg is the author of The Thalassaemia Syndromes, 4th Edition, published by Wiley.

Inhalt

Authors and Contributors.

Preface to the Fourth Edition.

Preface to the First Edition.

Acknowledgements.

Part 1 Historical Background.

1. Historical Perspectives: The Many and Diverse Routes to our
Current Understanding of the Thalassaemia Syndromes.

Part 2 The Biology of The Thalassaemias.

2. Human Haemoglobin.

3. Thalassaemia: Classification and Relationship to Other
Inherited Diseases of Haemoglobin.

4. The Molecular Pathology of the Thalassaemias.

5. Pathophysiology of the Thalassaemias.

6. The World Distribution and Population Genetics of
Thalassaemia.

Part 3 Clinical Features of the Thalassaemias .

7. The beta Thalassaemias.

8. The delta beta and Related Thalassaemias.

9. The beta and delta beta Thalassaemia in Association with
Structural Haemoglobin Variants.

10. Hereditary Persistence of Fetal Haemoglobin.

11. The alpha Thalassaemias and Their Interactions with
Structural Haemoglobin Variants.

12. Thalassaemia withmental retardation or Myelodysplasia.

13. Thalassaemia Intermedia.

Part 4 Diagnosis and management of thalassaemia. .

14. Avoidance and Population Control.

15. Management and prognosis.

16. Laboratory Diagnosis of the Thalassaemias.

Part 5 The Future.

References.

Appendix.

Index.

Rezensionen

"The book should be part of the library of every haematologist..."

JAMA on the Third Edition

"No library of any consequence should be without this up-to-date
reference volume."

South African Medical Journal on the Third
Edition

"...the only standard, comprehensive text...a must...They have done
a grand job."

Clinical and Laboratory Haematology on the Third
Edition

Produkt-Details

• Erscheint lt. Verlag: 30.4.2008
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Hämatologie
• Schlagworte: Hämatologie • Hämatologie • Hematology • Medical Science • Medizin
• ISBN-10: 0-470-69594-3 / 0470695943
• ISBN-13: 978-0-470-69594-4 / 9780470695944