BACE (eBook)

Lead Target for Orchestrated Therapy of Alzheimer's Disease

Varghese John (Autor)

eBook Download: PDF

2010 | 1. Auflage
272 Seiten
Wiley (Verlag)
978-0-470-59407-0 (ISBN)

Infos

BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE ( -site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and its role in AD and comprehensively discusses: The development of BACE inhibitors as therapeutics for Alzheimer's disease The research that led to the identification of BACE New BACE inhibitors currently being clinically tested ADME (absorption, distribution, metabolism, excretion) and clinical trial design topics not addressed in current field literature Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery Other approaches to BACE inhibition based on interaction with the precursor protein APP By enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's research and inspire new approaches to treatment of AD.

Autor

VARGHESE JOHN is Director of Alzheimer's Drug Discovery at the Buck Institute for Age Research. He is a chemist with many years of pharmaceutical industry experience in discovery and development of drugs for CNS diseases with a primary focus on Alzheimer's disease (AD). Dr. John has many publications and patents to his credit.

Rezensionen

"Overall this book is a timely and comprehensive resource covering
developments in BACE-targeted therapeutic agents from infancy to
the present time. It will prove to be valuable to researchers
working in the AD field, as well as to medicinal chemists seeking
to learn more about rational design of aspartyl protease
inhibitors." (ChemMedChem, November 2010)

Produkt-Details

• Erscheint lt. Verlag: 31.3.2010
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Geriatrie
• Themenwelt: Naturwissenschaften ► Chemie
• Schlagworte: Alzheimersche Krankheit • Biowissenschaften • Chemie • Chemistry • Drug Discovery & Development • Life Sciences • Medical Science • Medizin • Neuroscience • Neurowissenschaften • Pharmacology & Pharmaceutical Medicine • Pharmakologie u. Pharmazeutische Medizin • Wirkstoffforschung • Wirkstoffforschung u. -entwicklung
• ISBN-10: 0-470-59407-1 / 0470594071
• ISBN-13: 978-0-470-59407-0 / 9780470594070