Cardiotoxicity of Non-Cardiovascular Drugs (eBook)

Giorgio Minotti (Autor)

eBook Download: PDF

2010 | 1. Auflage
360 Seiten
John Wiley & Sons (Verlag)
978-0-470-66038-6 (ISBN)

Infos

Some drugs which are not aimed at treating heart disease have
nevertheless been found to have profound effects on heart muscle.
Cardiotoxicity is one of the major forms of toxicity seen in drugs
and it accounts for most drug recalls and delays experienced in
regulatory approvals.In recent years a number of non-cardiac
blockbuster drugs such as terfenadine have been withdrawn from
major markets because of cardiotoxicity concerns, while other drugs
have either been withdrawn prior to marketing or required labelling
changes that significantly restricted their use.

In Cardiotoxicity of Non-Cardiovascular Drugs
international experts describe the molecular mechanisms and
clinical read-outs of cardiac events induced by a broad variety of
noncardiovascular drugs. Particular emphasis is paid to the
preclinical screening of drug cardiotoxicity. Topics include:

* metabolic targets of cardiotoxicity

* regulatory aspects

* translating molecular mechanisms into clinical trials

* structure-activity relationships in arrhythmias by
antihistamines and psychoactive drugs

* cardiovascular toxicity of antitumor drugs

* cardiovascular toxicities of non-steroidal anti-inflammatory
drugs

* cardiovascular toxicities of antiretroviral therapies

Cardiotoxicity of Non-Cardiovascular Drugs is an
essential guide to this important area of drug development. It will
find a place on the bookshelves of researchers, regulators and
students in medicinal chemistry, drug development, pharmacology,
pharmacy and cardiovascular disease.

Autor

Professor Giorgio Minotti, M.D., PhD Professor Minotti is member of the Editorial Board of Cardiovascular Toxicology and Redox Report. He is currently developing an international network of scientists devoted to identifying and disseminating the scientific foundations, regulatory implications and clinical implications of cardiotoxicity induced by a number of noncardiovascular drugs. He has organised and chaired internation symposia on this subject at the EuroTox meetings in 2005 and 2007, and the International Workshop "Anthracycline Cardiotoxicity: Molecular Mechanisms and Clinical Correlates" in Como, October 2006.

Inhalt

Preface.

List of Contributors.

Abbreviations. .

1. Mitochondrial Dysfunction In Cell Injury and Cardiotoxicity
(Fabio Di Lisa, Martina Semenzato, Andrea Carpi, Sara Menazza,
Nina Kaludercic, Roberta Menabò, Marcella Canton).

2. Cardiovascular Liabilities of Drugs: Regulatory Aspects
(Claudio Arrigoni).

3. Cellular Mechanisms, Molecular Targets, and
Structure-Function Relationships In Drug-Induced Arrhythmias: The
Case Of Antihistamines, Psychoactive Drugs, and Antimicrobial
Agents (Maria Virginia Soldovieri and Maurizio
Taglialatela).

4. Cardiovascular Toxicity of Antitumor Drugs: Dimensions of the
Problem in Children (Rebecca Scully, Louis Pruitt, Steven E.
Lipshultz).

5. Cardiovascular Toxicity of Antitumor Drugs: Dimension of the
Problem in Adult Settings (Joseph R. Carver and Chaitali J.
Desai).

6. Diagnostic Aspects of Cardiovascular Toxicity of Antitumor
Drugs (Michael S. Ewer, Thomas M. Suter).

7. Cardiovascular Toxicity of Antitumor Drugs: Translating
Molecular Mechanisms into Clinical Facts (Pierantonio Menna,
Emanuela Salvatorelli, Carlo Salsano, Luca Gianni, and Giorgio
Minotti).

8. NSAID Action and the Foundations for Cardiovascular Toxicity
(Anna L. Blobaum and Lawrence J. Marnett).

9. Cardiovascular toxicities of NSAIDS: Epidemiologic aspects
(Antonio González-Pérez, Luis Alberto García
Rodriguez).

10. Cardiovascular Toxicities of Life-Saving Drugs: Antiviral
Therapy (James J. Kohler & William Lewis).

Index.

Produkt-Details

• Erscheint lt. Verlag: 25.3.2010
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Kardiologie / Angiologie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik
• Schlagworte: Chemie • Chemistry • Medical Science • Medizin • Pharmacology & Pharmaceutical Medicine • Pharmakologie • Pharmakologie u. Pharmazeutische Medizin • Toxicology • Toxikologie
• ISBN-10: 0-470-66038-4 / 0470660384
• ISBN-13: 978-0-470-66038-6 / 9780470660386