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Bipolar Psychopharmacotherapy (eBook)

Caring for the Patient
eBook Download: PDF
2006 | 1. Auflage
414 Seiten
Wiley (Verlag)
978-0-470-03230-5 (ISBN)

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Bipolar disorder is often not recognized as an illness, and people may suffer for years before it is properly diagnosed and treated. Like diabetes or heart disease, bipolar disorder is a long-term illness that must be carefully managed throughout a person's life. Pharmacotherapy is central to the acute treatment and long-term management of the disorder and as there are several classes of drugs, which are often prescribed concurrently, treatment issues are complex.

This essential reference work examines major pharmacological treatments in the different phases of bipolar disorder. Chapters are devoted to commonly use pharmacological treatments with a critical review of the existing literature. Each chapter includes information not only on studies that have been published but also on new treatments that have been reported in peer reviewed scientific meetings.

Bipolar Psychopharmacotherapy covers both pharmacotherapy and the role of psychotherapy, psychoeducation and social approaches to provide a broad integrative philosophy of care for bipolar patients. Extensive coverage is given to special management issues such as the care of women with bipolar disorder, children and the elderly, as well as bipolar depression and suicide prevention.

With contributions from the pioneers in the field and an expert editor team, Bipolar Psychopharmacotherapy provides psychiatrists and all mental health practitioners with an invaluable guide to the management of these complex patients.

From the reviews:

'If a colleague were to ask me, 'What would you recommend I read if I want to become a real expert on bipolarity?' I would respond 'Bipolar Psychopharmacotherapy: Caring for the Patient'.' JOURNAL OF BIPOLAR DISORDERS

'... a very useful reference on the pharmacological treatment of bipolar disorder that is written in a very practical and user-friendly format... a must for anyone dealing with patients with bipolar disorder.' DOODY'S HEALTH SERVICES

'... a multifaceted text with broad clinical value... recommended as an in-office reference for the practicing physician who treats the bipolar patients... to all Health Science libraries as a general reference text.' THE ELECTRIC REVIEW



Hagop Akiskal, Distinguished Professor of Psychiatry, Director of International Mood Center, University of California at San Diego, La Jolla, California, USA. Professor Akiskal was awarded the Jean Delay prize by the World Psychiatric Association in 2002 for research work that better bridges the gap between biological, psychological and social aspects of psychiatry and mental health. He has received the Gold Medal for Pioneer Research (Society of Biological Psychiatry), the German Anna Monika Prize for Depression, the NARSAD Prize for Affective Disorders, the French Jules Baillarger and the Italian Aretaeus Prizes for his research on the bipolar spectrum. He is Editor-in-Chief of the Journal of Affective Disorders.

Mauricio Tohen, Professor and Head of the Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Science Centre, San Antonio, Texas, USA. Professor Tohen is President of The International Society for Bipolar Disorders, 2010 - 2012.

Dr. Tohen obtained his MD degree from the National University of Mexico. He completed a residency in Psychiatry at the University of Toronto and a Fellowship in Psychopharmacology at McLean Hospital, Harvard Medical School. He obtained his doctorate in Epidemiology from the Harvard School of Public Health and an MBA from the University of Indiana. From 1988 to 1997 he was the clinical Director of the Bipolar and Psychotic Disorders Program at McLean Hospital. From 1997 to 2008 he worked at Lilly Research Laboratories in Indianapolis, Indiana where he reached the most senior scientific rank of Distinguished Lilly Scholar. In 2009 he was appointed to the Krus endowed chair in Psychiatry at the University of Texas Health Science Centre at San Antonio. His research has focused on the clinical epidemiology and psychopharmacological treatments of bipolar disorder. Professor Tohen has over 200 original publications and over 500 book chapters and scientific abstracts. He has co-edited Mood Disorders Across the Lifespan and Textbook of Psychiatric Epidemiology, and has also edited Comorbidity in Affective Disorders.


Bipolar disorder is often not recognized as an illness, and people may suffer for years before it is properly diagnosed and treated. Like diabetes or heart disease, bipolar disorder is a long-term illness that must be carefully managed throughout a person's life. Pharmacotherapy is central to the acute treatment and long-term management of the disorder and as there are several classes of drugs, which are often prescribed concurrently, treatment issues are complex. This essential reference work examines major pharmacological treatments in the different phases of bipolar disorder. Chapters are devoted to commonly use pharmacological treatments with a critical review of the existing literature. Each chapter includes information not only on studies that have been published but also on new treatments that have been reported in peer reviewed scientific meetings. Bipolar Psychopharmacotherapy covers both pharmacotherapy and the role of psychotherapy, psychoeducation and social approaches to provide a broad integrative philosophy of care for bipolar patients. Extensive coverage is given to special management issues such as the care of women with bipolar disorder, children and the elderly, as well as bipolar depression and suicide prevention. With contributions from the pioneers in the field and an expert editor team, Bipolar Psychopharmacotherapy provides psychiatrists and all mental health practitioners with an invaluable guide to the management of these complex patients. From the reviews: If a colleague were to ask me, What would you recommend I read if I want to become a real expert on bipolarity? I would respond Bipolar Psychopharmacotherapy: Caring for the Patient . JOURNAL OF BIPOLAR DISORDERS "e;... a very useful reference on the pharmacological treatment of bipolar disorder that is written in a very practical and user-friendly format... a must for anyone dealing with patients with bipolar disorder."e; DOODY'S HEALTH SERVICES "e;... a multifaceted text with broad clinical value recommended as an in-office reference for the practicing physician who treats the bipolar patients to all Health Science libraries as a general reference text."e; THE ELECTRIC REVIEW

Hagop Akiskal, Distinguished Professor of Psychiatry,Director of International Mood Center, University of California atSan Diego, La Jolla, California, USA. Professor Akiskal was awardedthe Jean Delay prize by the World Psychiatric Association in 2002for research work that better bridges the gap between biological,psychological and social aspects of psychiatry and mental health.He has received the Gold Medal for Pioneer Research (Society ofBiological Psychiatry), the German Anna Monika Prize forDepression, the NARSAD Prize for Affective Disorders, the FrenchJules Baillarger and the Italian Aretaeus Prizes for his researchon the bipolar spectrum. He is Editor-in-Chief of the Journal ofAffective Disorders. Mauricio Tohen, Professor and Head of the Division ofMood and Anxiety Disorders, Department ofPsychiatry, University of Texas Health ScienceCentre, San Antonio, Texas, USA. Professor Tohenis President of The International Society for BipolarDisorders, 2010 - 2012. Dr. Tohen obtained his MD degree from the National University ofMexico. He completed a residency in Psychiatry at the University ofToronto and a Fellowship in Psychopharmacology at McLean Hospital,Harvard Medical School. He obtained his doctorate in Epidemiologyfrom the Harvard School of Public Health and an MBA from theUniversity of Indiana. From 1988 to 1997 he was the clinicalDirector of the Bipolar and Psychotic Disorders Program at McLeanHospital. From 1997 to 2008 he worked at Lilly ResearchLaboratories in Indianapolis, Indiana where he reached the mostsenior scientific rank of Distinguished Lilly Scholar. In 2009 hewas appointed to the Krus endowed chair in Psychiatry at theUniversity of Texas Health Science Centre at San Antonio. His research has focused on the clinical epidemiology andpsychopharmacological treatments of bipolar disorder. ProfessorTohen has over 200 original publications and over 500 book chaptersand scientific abstracts. He has co-edited Mood Disorders Acrossthe Lifespan and Textbook of Psychiatric Epidemiology,and has also edited Comorbidity in Affective Disorders.

Bipolar Psychopharmacotherapy 3
Contents 9
List of Contributors 11
Preface 15
Chapter 1 The Scope of Bipolar Disorders 17
Chapter 2 Lithium Treatment: Focus on Long-Term Prophylaxis 25
Chapter 3 Valproate: Clinical Pharmacological Profile 43
Chapter 4 Pharmacological Profile and Clinical Utility of Lamotrigine in Bipolar Disorders 59
Chapter 5 Carbamazepine, Other Anticonvulsants and Augmenting Agents 79
Chapter 6 Olanzapine in Treatment for Bipolar Disorder 101
Chapter 7 Haloperidol and Risperidone in Mania 121
Chapter 8 A Comparison of “Second Generation Antipsychotics” in the Treatment for Bipolar Disorder: Focus on Clozapine, Quetiapine, Ziprasidone and Aripiprazole 141
Chapter 9 Complex Combination Therapy: The Evolution Toward Rational Polypharmacy in Lithium-Resistant Bipolar Illness 151
Chapter 10 The Primacy of Mania 185
Chapter 11 Diagnostic and Clinical Management Approaches to Bipolar Depression, Bipolar II and Their Comorbidities 209
Chapter 12 Bipolarity in Women: Therapeutic Issues 251
Chapter 13 Pediatric Bipolar Disorder: The Promise of Psychopharmacotherapy 295
Chapter 14 Treatment for Bipolar Disorder in Older Adults 317
Chapter 15 Psychosocial Interventions in Bipolar Disorders: Rationale and Effectiveness 329
Chapter 16 The Pivotal Role of Psychoeducation in the Long-Term Treatment of Bipolar Disorder 349
Chapter 17 The Role of Treatment Setting in the Pharmacotherapy of Bipolar Disorder 363
Chapter 18 Suicide Prevention 369
Chapter 19 Principles of Caring for Bipolar Patients 383
Index 405

"...an extremely up-to-date, comprehensive book for clinicians...Iwould recommend it for every clinical psychiatrist whose practiceincludes bipolar patients." (American Journal of Psychiatry,February 2007)

"...readers will not be able to find a more comprehensive andup-to-date review of the main therapeutic approaches to bipolaraffective disorder..." (New England Journal of Medicine,September 21, 2006)

"This is a book that will have a prominent place in my alreadybursting library for a long time to come because of its value to meas a researcher, scholar, and teacher." (The Annals ofPharmacotherapy, September 2006)

"...a very useful reference on the pharmacological treatment ofbipolar disorder that is written in a very practical anduser-friendly format...a must for anyone dealing with patients withbipolar disorder." (Doody's Health Services)

"...a multifaceted text with broad clinicalvalue...recommended as an in-office reference for thepracticing physician who treats the bipolar patients...to allHealth Science libraries as a general reference text." (TheElectric Review, March/April 2006)

Erscheint lt. Verlag 14.6.2006
Sprache englisch
Themenwelt Medizin / Pharmazie Gesundheitsfachberufe
Medizin / Pharmazie Medizinische Fachgebiete Psychiatrie / Psychotherapie
Schlagworte Medical Science • Medizin • Pharmacology & Pharmaceutical Medicine • Pharmakologie u. Pharmazeutische Medizin • Psychiatrie • Psychiatry
ISBN-10 0-470-03230-8 / 0470032308
ISBN-13 978-0-470-03230-5 / 9780470032305
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