Glutathione

Biochemistry, Mechanisms of Action & Biotechnological Implications

Nikolaos Labrou, Emmanouil Flemetakis (Herausgeber)

Buch | Hardcover

394 Seiten

2013
Nova Science Publishers Inc (Verlag)
978-1-62417-460-5 (ISBN)

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Glutathione ( -glutamyl-cysteinyl-glycine; GSH) is the most abundant low-molecular-weight thiol found in both prokaryotic and eukaryotic organisms. GSH has potent electron-donating capacity that renders GSH both a potent antioxidant and a conventional cofactor for enzymatic reactions. GSH participates in many cellular functions such as redox control, stress defense, drug detoxification and cell signaling including regulation of DNA and protein synthesis, gene expression, apoptosis and cell proliferation. GSH concentration in the cell is homeostatically controlled, being continually self-adjusting with respect to the balance between GSH synthesis, its recycling from GSSG and its utilization by other enzymes. Alterations in its concentration contribute to oxidative stress, which plays a key role in aging and the pathogenesis of many diseases associated with redox processes modulation. This book discusses cutting-edge developments and deals with the information gained over the last few years on the physiological, biochemical and molecular roles of the GSH and its significance in mammalian, microbial and plant cells.

Preface; Glutathione: Biosynthesis & Mechanism of Action; Central Functions of Glutathione & Peptides & Amino Acids Related to Glutathione Synthesis & Metabolism, on Stress Responses.

Verlagsort	New York
Sprache	englisch
Maße	180 x 260 mm
Gewicht	840 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	1-62417-460-4 / 1624174604
ISBN-13	978-1-62417-460-5 / 9781624174605
Zustand	Neuware