Novel Therapeutic Targets for Antiarrhythmic Drugs (eBook)

George Edward Billman (Autor)

eBook Download: PDF

2010 | 1. Auflage
608 Seiten
John Wiley & Sons (Verlag)
978-0-470-56140-9 (ISBN)

Infos

PROFILES POTENTIAL TREATMENT APPROACHES FOR CARDIAC ARRHYTHMIAS

Cardiac arrhythmias of ventricular origin are responsible for the deaths of nearly half a million Americans each year while atrial fibrillation accounts for about 2.3 million cases per year, a rate that is projected to increase 2.5 fold over the next half century. Effectively managing these cardiac rhythm disorders remains a major challenge for both caregivers and the pharmaceutical industry. Filling a gap in the current literature, Novel Therapeutic Targets for Antiarrhythmic Drugs presents the latest treatments for cardiac arrhythmias alongside comprehensive presentations of basic cardiac physiology and pharmacology.

Written by leading experts in their research areas, this invaluable resource offers both practitioners and researchers a one-stop guide that brings together previously dispersed information. The text consists of four sections:

* Section One comprehensively reviews basic cardiac electrophysiology, the mechanisms responsible for arrhythmias in the setting of ischemia, and basic pharmacology of antiarrhythmic drugs.

* Section Two addresses safety pharmacology, including the concept of "repolarization reserve," safety challenges, and regulatory issues for the development of novel antiarrhythmic drugs.

* Section Three describes several novel pharmacological targets for antiarrhythmic drugs, including both ion channel and non-ion channel targets.

* Section Four describes promising non-pharmacological antiarrhythmic interventions including selective cardiac neural disruption or nerve stimulation, aerobic exercise training, and diet (omega-3 fatty acids).

Offering an unparalleled look at the current state and future direction of cardiac arrhythmia treatment, Novel Therapeutic Targets for Antiarrhythmic Drugs provides an important resource to advanced students, working researchers, and busy professionals alike.

Autor

GEORGE EDWARD BILLMAN is a professor at The Ohio State University. He is currently an Associate Editor of Pharmacology and Therapeutics, an Editor of Experimental Physiology, and on the editorial boards of Journal of Cardiovascular Pharmacology and Journal of Applied Physiology. Dr. Billman has authored over 125 journal articles and has been an invited speaker at twenty national and international scientific meetings. He wrote the chapter "Cardiac Sarcolemmal ATP-Sensitive Potassium Channel Antagonists" in Drug Discovery Handbook (Wiley).

Inhalt

Acknowledgments.

Contributors.

1. Introduction (George E. Billman).

2. Myocardial K¯+ Channels: Primary Determinants of Action Potential Repolarization (Noriko Niwa and Jeanne Nerbonne).

3. The "Funny" Pacemaker Current (Andrea Barbuti, Annalisa Bucchi, Mirko Baruscotti, and Dario DiFrancesco).

4. Arrhythmia Mechanisms in Ischemia and Infarction (Ruben Coronel, Wen Dun, Penelope A. Boyden, and Jacques M.T. de Bakker).

5. Antiarrhythmic Drug Classification (Cynthia A. Carnes).

6. Repolarization Reserve and Proarrhythmic Risk (András Varró).

7. Safety Challenges in the Development of Novel Antiarrhythmic Drugs (Gary Gintant and Zhi Su).

8. Safety Pharmacology and Regulatory Issues in the Development of Antiarrhythmic Medications (Armando Lagrutta and Joseph J. Salata).

9. Ion Channel Remodeling and Arrhythmias (Takeshi Aiba and Gordon F. Tomaselli).

10. Redox Modification of Ryanodine Receptors in Cardiac Arrhythmia and Failure: A Potential Therapeutic Target (Andriy E. Belevych, Dmitry Terentyev, and Sandor Györke).

11. Targeting Na ¯+ /Ca¯2+ Exchange as an Antiarrhythmic Strategy (Gudrun Antoons, Rik Willems, and Karin R. Sipido).

12. Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII)-Modulation of Ion Currents and Potential Role for Arrhythmias (Dr. Lars S. Maier).

13. Selective Targeting of Ventricular Potassium Channels for Arrhythmia Suppression: Feasible or Risible? (Hugh Clements-Jewery and Michael Curtis).

14. Cardiac Sarcolemmal ATP-sensitive Potassium Channel Antagonists: A Class of Drugs that May Selectively Target the Ischemic Myocardium (George E. Billman).

15. Mitochondrial Origin of Ischemia-Reperfusion Arrhythmias (Brian O'Rourke, PHD).

16. Cardiac Gap Junctions: A New Target for New Antiarrhythmic Drugs: Gap Junction Modulators (Anja Hagen and Stefan Dhein).

17. Novel Pharmacological Targets for the Management of Atrial Fibrillation (Alexander Burashnikov and Charles Antzelevitch).

18. Ikur, Ultra-rapid Delayed Rectifier Potassium Current: A Therapeutic Target for Atrial Arrhythmias (Arun Sridhar and Cynthia A. Carnes).

19. Non-Pharmacologic Manipulation of the Autonomic Nervous System in Human for the Prevention of Life-Threatening Arrhythmias (Peter J. Schwartz).

20. Effects of Endurance Exercise Training on Cardiac Autonomic Regulation and Susceptibility to Sudden Cardiac Death: A Nonpharmacological Approach for the Prevention of Ventricular Fibrillation (George E. Billman).

21. Dietary Omega-3 Fatty Acids as a Nonpharmacological Antiarrhythmic Intervention (Barry London and J. Michael Frangiskakis).

General Index.

Index of Drug and Chemical Names.

Rezensionen

"In Summary, the book is a good, comprehensive reference for
knowledge on arrhythmia and its treatment, and is considered as
worthwhile addition to the literature on cardiac arrhythmia and
antiarrhythmic drugs." (ChemMedChem, July 2010)

"George Billman has assembled a terrific book that will serve the
needs of students, clinical and research faculty with interests in
cardiac arrhythmias, antiarrhythmic drugs and ion channel biology."

--Mark E. Anderson, M.D., Ph.D. Professor, Departments
of Internal Medicine and Molecular Physiology & Biophysics
Head, Department of Internal Medicine François M. Abboud Chair
in Internal Medicine

"The information presented in each individual chapter is of
superb quality, still providing the information in such a detailed
way that even the knowledge of the specialists in the field will be
challenged. The topics covered, however, are so broad that the
mentioned specialist will also find chapters of great interest to
his common knowledge in other fields. In this era of PubMed, the
younger scientists will be pleased to find detailed referencing,
including papers going back many decades, revealing information
well in the last century. Therefore, I recommend this book to
individuals still interested in the mechanism behind arrhythmias
and the way that this knowledge can be applied to new therapeutic
strategies."

--Marc Vos, PhD, University Medical Center Utrecht

Produkt-Details

• Erscheint lt. Verlag: 21.1.2010
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Kardiologie / Angiologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Naturwissenschaften ► Chemie
• Schlagworte: Antiarrhythmika • Arzneimittelentwicklung • Cardiovascular Disease • Chemie • Chemistry • Drug Discovery & Development • Kardiovaskuläre Erkrankung • Kardiovaskuläre Erkrankungen • Kardiovaskuläre Erkrankung • Kardiovaskuläre Erkrankungen • Medical Science • Medizin • Pharmacology & Pharmaceutical Medicine • Pharmakologie u. Pharmazeutische Medizin • Wirkstoffforschung u. -entwicklung
• ISBN-10: 0-470-56140-8 / 0470561408
• ISBN-13: 978-0-470-56140-9 / 9780470561409