Polyphosphazenes for Biomedical Applications (eBook)

A. K. Andrianov (Herausgeber)

eBook Download: PDF

2009 | 1. Auflage
480 Seiten
John Wiley & Sons (Verlag)
978-0-470-47887-5 (ISBN)

Infos

Brings together, analyzes, and contextualizes the latest
findings and practical applications

Polyphosphazenes, an emerging class of polymers, include
macromolecules, which have been proven to be biocompatible,
biodegradable, and bioactive. Their unprecedented structural
diversity and unique properties make them suitable as vaccine
adjuvants, microencapsulating agents, biodegradable materials,
scaffolds for tissue engineering, biocompatible coatings, and
carriers for gene delivery.

Polyphosphazenes for Biomedical Applications offers a
thorough review of polyphosphazene research findings in the life
sciences, chemistry, and chemical engineering. It emphasizes
biomedical applications as well as recent advances in
polyphosphazene development such as high-throughput discovery and
the latest controlled methods of synthesis. The book brings
together, analyzes, and contextualizes a wealth of knowledge that
previously could only be found scattered throughout the scientific
literature.

Following two introductory chapters, the book reviews:

* Vaccine delivery and immunomodulation

* Biomaterials

* Drug delivery systems

* Biodetection

* Well-defined polyphosphazenes: synthetic aspects and novel
molecular architectures

All the chapters have been written by leading researchers in the
field. Editor Alexander Andrianov, who has led the effort to
commercialize polyphosphazenes for biomedical applications, has
carefully reviewed and edited all chapters to ensure readability,
accuracy, and thoroughness.

Polyphosphazenes for Biomedical Applications is not only
intended for researchers working in polyphosphazene chemistry, but
also for all researchers seeking solutions to problems arising in
the areas of biomaterials, drug delivery systems, and controlled
release formulations.

Autor

Alexander K. Andrianov, PhD, is a Vice President of Research and Development at Apogee Technology, Inc. Dr. Andrianov has more than 25 years of experience in the discovery and development of novel polymers for biological applications, including biodegradable materials, vaccine adjuvants, macromolecules for microencapsulation, controlled release formulations, and transdermal drug delivery systems. He is an author of over 60 research manuscripts, review articles, and book chapters and an inventor with 41 issued and pending patents. Dr. Andrianov has been involved in all aspects of technology development and commercialization.

Inhalt

CONTRIBUTORS.

PREFACE.

I INTRODUCTION.

1 Polymers for Biology and Medicine - Current Status and Future
Prospects (Alexander K. Andrianov and Robert Langer).

2 Expanding Options in Polyphosphazene Biomedical Research
(Harry R. Allcock).

II VACCINE DELIVERY AND IMMUNOMODULATION.

3 Polyphosphazenes as Vaccine Delivery Systems (Alexander K.
Andrianov).

4 The Potential of Polyphosphazenes in Modulating
Vaccine-Induced Immune Responses I: Investigations In Mice
(George Mutwiri, Ponn Benjamin, Alexander K. Andrianov, and
Lorne Babiuk).

5 The Potential of Polyphosphazenes in Modulating
Vaccine-Induced Immune Responses II: Investigations In Large
Animals (George Mutwiri and Lorne Babiuk).

6 Polyphosphazenes as Adjuvants for Inactivated and Subunit
Rotavirus Vaccines in Adult and Infant Mice (Kari Johansen,
Jorma Hinkula, Claudia Istrate, Elin Johansson, Didier Poncet, and
Lennart Svensson).

7 Polyphosphazene Immunoadjuvants for Intradermal Vaccine
Delivery (Alexander K. Andrianov, Daniel P. DeCollibus, Helice
A. Gillis, Henry H. Kha, Alexander Marin).

III BIOMATERIALS.

8 Biodegradable Polyphosphazene Scaffolds for Tissue Engineering
(Syam P. Nukavarapu, Sangamesh G. Kumbar, Harry R. Allcock and
Cato T. Laurencin).

9 Biodegradable Polyphosphazene Blends for Biomedical
Applications (Meng Deng, Lakshmi S. Nair, Nicholas R. Krogman,
Harry R. Allcock, Cato T. Laurencin).

10 Polyphosphazenes from Condensation Polymerization (Patty
Wisian-Neilson).

11 Electrospun Polyphosphazene Nanofibers For In Vitro
Osteoblast Culture (Maria Teresa Conconi, Paolo Carampin,
Silvano Lora, Claudio Grandi, Pier Paolo Parnigotto).

12 Phosphazenes and Surfaces (Mario Gleria, Roberto Milani,
Roberta Bertani, Angelo Boscolo Boscoletto, and Roger De
Jaeger).

IV DRUG DELIVERY SYSTEMS.

13 Amphiphilic Ionizable Polyphosphazenes for the Preparation of
pH-Responsive Liposomes (David Ghattas and Jean-Christophe
Leroux).

14 Poly- and Cyclophosphazenes as Drug Carriers for Anticancer
Therapy (Youn Soo Sohn and Yong Joo Jun).

15 Amphiphilic Polyphosphazenes as Drug Carriers (Liyan Qiu
and Cheng Zheng).

16 Synthesis and Characterization of Organometallic Derivatives
of Polyphosphazenes and their Applications in Nanoscience
(Carlos Diaz and M. L. Valenzuela).

17 Transport Properties of Polyphosphazenes (Joel R.
Fried).

V BIODETECTION.

18 Potentiometric Monitoring Antibody-Antigen Interactions
by and Stabilization of Polyanilineand Electrodes with
p-Sulfonated Poly(bisphenoxyphosphazene) (Byeongyeol Kim,
Alexander K. Andrianov, Alok Prabhu, Vladimir Sergeyev, and Kalle
Levon).

VI WELL-DEFINED POLYPHOSPHAZENES: SYNTHETIC ASPECTS AND NOVEL
MOLECULAR ARCHITECTURES.

19 Synthesis and chemical regularity in phosphazene copolymers
(Gabino A. Carriedo).

20 Supramolecular Structures of Cyclophosphazenes(Alexander
Steiner

APPENDIX A.

INDEX.

Produkt-Details

• Erscheint lt. Verlag: 11.8.2009
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Biomedizin
• Themenwelt: Medizin / Pharmazie ► Pflege
• Themenwelt: Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Themenwelt: Technik ► Medizintechnik
• Schlagworte: biomedical engineering • Biomedizinische Technik • Biomedizintechnik • Biotechnologie i. d. Chemie • Biotechnology • Chemie • Chemistry • Polymer Science & Technology • Polymerwissenschaft u. -technologie
• ISBN-10: 0-470-47887-X / 047047887X
• ISBN-13: 978-0-470-47887-5 / 9780470478875